脑梗死患者CagA阳性幽门螺杆菌感染同颈动脉粥样硬化的相关性研究  

Association of CagA-Positive Helicobacter Pylori Strains Infection with Carotid Atherosclerosis

作　　者：李晓红[1] 尹琳[2] 刘萍[1] 

机构地区：[1]辽宁省大连市友谊医院神经内科,116001 [2]大连医科大学附属二院神经内科,116023

出　　处：《中国误诊学杂志》2008年第31期7561-7563,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:研究脑梗死患者细胞毒素相关蛋白(CagA)阳性幽门螺杆菌(HP)感染同颈动脉内膜厚度(IMT)及斑块数量之间的关系,探讨HP及其CagA阳性菌株的感染同动脉粥样硬化的相关性。方法:对发病1周内的70例脑梗死患者调查传统高危因素情况,检测血清中HP.IgG和CagA-HP.IgG的浓度和阳性率(ELISA法),超声测量颈总动脉IMT值和动脉粥样硬化斑块数量。结果:(1)CagA-HP.IgG阳性组颈总动脉IMT值明显高于阴性组,有显著性差异;(2)CagA-HP.IgG阳性者中血清CagA-HP.IgG浓度同颈总动脉IMT值和动脉粥样硬化斑块数量呈正相关。结论:脑梗死患者中产CagA的HP高毒力菌株的感染可能同颈总动脉动脉粥样硬化进展程度有关。Objective：To assess the relationship between CagA-positive Helicobacter pylori strains infection and carotid atherosclerosis in patients with cerebral infarction. Methods：IgG antibodies against HP and CagA protein were determined （enzyme immunoassays） in 70 patients with acute cerebral infarction. Traditional risk factors,such as hypertension ,hyperlipidemia ,diabetes mellitus and smoking were investigated. Intima-media thickness （IMT） and atheroselerotic plaques of common carotid artery （CCA） were thoroughly assessed by high-resolution duplex scanning. T-test was used for the statistical analysis. Results ： （1） Intima-media thickness of CCA was higher in CagA-HP. IgG positive patients. （2）The level of CagA-HP. IgG was positively relevant to the IMT and plaques of CCA in CagA-HP. IgG pasitive patients. Conclusions ：CagA seropositivity may due to the pathogenesis of carotid atherosclerosis in patients with cerebral ischemia.

关 键 词：脑梗塞/病因学 螺杆菌感染 抗原 细菌/血液 细菌蛋白质类/血液 螺杆菌 幽门 颈动脉疾病/并发症 人类 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R543.4[医药卫生—临床医学]