Role of mucosal dendritic cells in inflammatory bowel disease  

作　　者：Jan Hendrik Niess 

机构地区：[1]Department of Internal Medicine I, Ulm University,Ulm 89031, Germany

出　　处：《World Journal of Gastroenterology》2008年第33期5138-5148,共11页世界胃肠病学杂志（英文版）

基　　金：The Deutsche Forschungsgemeinschaft, No. Ni575/4-1

摘　　要：The gastrointestinal innate and adaptive immune system continuously faces the challenge of potent stimuli from the commensal microflora and food constituents. These local immune responses require a tight control, the outcome of which is in most cases the induction of tolerance. Local T cell immunity is an important compartment of the specif ic intestinal immune system. T cell reactivity is programmed during the initial stage of its activation by professional presenting cells. Mucosal dendritic cells (DCs) are assumed to play key roles in regulating immune responses in the antigen-rich gastrointestinal environment. Mucosal DCs are a heterogeneous population that can either initiate (innate and adaptive) immune responses, or control intestinal inflammation and maintain tolerance. Defects in this regulation are supposed to lead to the two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). This review will discuss the emerging role of mucosal DCs in regulating intestinal inflammation and immune responses.The gastrointestinal innate and adaptive immune system continuously faces the challenge of potent stimuli from the commensal microflora and food constituents. These local immune responses require a tight control, the outcome of which is in most cases the induction of tolerance. Local T cell immunity is an important compartment of the specif ic intestinal immune system. T cell reactivity is programmed during the initial stage of its activation by professional presenting cells. Mucosal dendritic cells （DCs） are assumed to play key roles in regulating immune responses in the antigenrich gastrointestinal environment. Mucosal DCs are a heterogeneous population that can either initiate （innate and adaptive） immune responses, or control intestinal inflammation and maintain tolerance. Defects in this regulation are supposed to lead to the two major forms of inflammatory bowel disease （IBD）, Crohn＇s disease （CD） and ulcerative colitis （UC）. This review will discuss the emerging role of mucosal DCs in regulating intestinal inflammation and immune responses.

关 键 词：Dendritic cells COMMENSAL Inflammatory bowel disease Mucosal immunity Host defence 

分 类 号：R574[医药卫生—消化系统]