肝动脉化疗栓塞术后补充经皮无水乙醇注射术治疗原发性肝细胞癌  

Efficacy of percutaneous ethanol injection in the adjuvant treatment of hepatocellular carcinoma after TACE

作　　者：林海澜[1] 郝明志[1] 沈友宏[2] 郑建雄[1] 唐丽娜[2] 阎若元[2] 陈静[2] 吴周贵[2] 陈起忠[1] 

机构地区：[1]福建省肿瘤医院介入科 [2]福建省肿瘤医院B超室,福建福州350014

出　　处：《中国介入影像与治疗学》2008年第5期378-381,共4页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的本研究旨在评价肝动脉化疗栓塞术后经皮无水乙醇注射术补充治疗对原发性肝细胞癌(HCC)疾病进程和总生存期的影响。方法全部73例HCC,临床分期均为中国分期Ⅱ期,并接受至少2次肝动脉栓塞化疗。治疗组22例,于肝动脉栓塞化疗(TACE)后补充经皮无水乙醇消融术(PEI),对照组51例TACE后未予补充治疗,比较两组疾病进展时间与生存期差异,并作预后因素分析。结果治疗组与对照组中位疾病进展时间分别为10个月(95%可信区间7.9,12.1)和6个月(95%可信区间4.7,7.3)。治疗组3个月、6个月、1年无进展生存率为77.30%、63.61%、48.12%,对照组3个月、6个月、1年无疾病进展率为76.51%、42.17%、24.82%,两组有显著差别(log-rank检验,P<0.05)。两组中位生存期分别为17个月(95%可信区间11,23)、12个月(95%可信区间10,14),总生存期无显著差异(P>0.05)。结论TACE术后补充PEI能明显延长HCC无进展生存期。Objective To evaluate the efficacy of percutaneous ethanol injection （PEI） in the adjuvant treatment of hepatocellular carcinoma （HCC） after tanscatheter arterial chemoembolization （TACE）. Methods The study population consisted of 73 consecutive patients with unreseetable HCC （China Classification System IIA/IIB）, among them 22 were trea ted with TACE and PEI （experimental group）, and the rest 51 were treated only with TACE （control group）, and then the time to progress （TTP） and overall survival （OS） of these two groups were analyzed. Results The median TTP was 10 months [95%confidence interval （CI）, 7.9--12. 1 months] in experimental group and 6 months （95% CI, 4.7--7.3 months） in control group. The progression free survival （PFS） rate of 3 months, 6 months and 1 year was 77.30%, 63.61%, and 48.12% of experimental group, respectively, while was 76.51%, 42. 17% and 24.82% of control group, respectively. The TTP of experimental group was significantly longer than that of control group （P〈0. 05）. The median survival period was 17 months [95% confidence interval （CI）, 11--23 months] of experimental group and 12 months （95% CI, 10--14 months） of control group （P〉0.05）. Conclusion Compared with single TACE, the combination of TACE and PEI can obviously postpone disease progress and prolong survival of HCC patients.

关 键 词：肝肿瘤 化学栓塞 治疗性 乙醇 疾病进展时间 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]