Obestatin及其受体与胃肠动力  

Roles of obestatin and its receptor in regulation of gastrointestinal motility

作　　者：吴祯乾[1] 王维刚[1] 王志刚[1] 郑起[1] 

机构地区：[1]上海交通大学附属第六人民医院普外科,上海市200233

出　　处：《世界华人消化杂志》2008年第26期2974-2979,共6页World Chinese Journal of Digestology

摘　　要：肥胖抑制素(Obestatin)是一个胃合成的由23个氨基酸组成的酰胺化的脑肠肽,他能够与孤儿G蛋白偶联受体GPR39结合,产生抑制摄食、减缓体质量增加、抑制胃排空和小肠收缩活动的生物学功能.Obestatin和Ghrelin是由同一条Ghrelin基因经翻译后加工修饰而行成的两条不同多肽,但Obestatin表现出与Ghrelin截然相反的生物学作用.然而,最近有研究怀疑以上发现的真实性.鉴于Obestatin可能不是GPR39的受体以及Obestatin对胃肠调节没有作用的争论,本文主要就Obestatin及其受体和Obestatin对胃肠动力的调节作用等相关研究成果作一概述.Obestatin,a novel 23-amino acid amidated brain/gut peptide synthesized in the stomach, was initially reported to reduce food intake, body weight gain and gastric emptying and suppress intestinal motility through an interaction with the orphan Grotein coupled receptor GPR39.Obestatin is derived from the same gene product as ghrelin by differential posttranslational processing and modification,which exerts effects opposite to those of ghrelin.However, recent reports have shown that the above findings had been questioned by several groups. According to the controversy that obestatin is unlikely to be the endogenous ligand for GPR39 and obestatin has no impacts on gastrointestinal motility,this paper reviews the studies related to obestatin and GPR39 and its impacts on gastrointestinal motility.

关 键 词：肥胖抑制素 GHRELIN 孤儿G蛋白偶联受体 胃肠动力 

分 类 号：R57[医药卫生—消化系统]