Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: A case report  

作　　者：Atsushi Takahashi Yukiko Kanno Yuta Takahashi Natsumi Sakamoto Kyoko Monoe Hironobu Saito Kazumichi Abe Junko Yokokawa Atsushi Irisawa Hiromasa Ohira 

机构地区：[1]Department of Internal Medicine Ⅱ,Fukushima Medical University School of Medicine,Fukushima,Japan

出　　处：《World Journal of Gastroenterology》2008年第35期5474-5477,共4页世界胃肠病学杂志（英文版）

摘　　要：A 43-year-old woman with multiple sclerosis （MS） was treated with pulsed methylprednisolone and interferon 13 at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the criteria for drug-induced hepatitis, but not for autoimmune hepatitis （AIH）. She was successfully treated with corticosteroids. As ataxia developed after i year, she was treated with pulsed methylprednisolone for 3 days, then readmitted to our hospital when liver dysfunction occurred. Clinical and laboratory findings led to the diagnosis of AIH. To the best of our knowledge, this is the second case of AIH developed after pulsed methylprednisolone for MS.A 43-year-old woman with multiple sclerosis (MS) was treated with pulsed methylprednisolone and interferon β at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the criteria for drug-induced hepatitis, but not for autoimmune hepatitis (AIH). She was successfully treated with corticosteroids. As ataxia developed after 1 year, she was treated with pulsed methylprednisolone for 3 d, then readmitted to our hospital when liver dysfunction occurred. Clinical and laboratory findings led to the diagnosis of AIH. To the best of our knowledge, this is the second case of AIH developed after pulsed methylprednisolone for MS.

关 键 词：Multiple sclerosis Autoimmune hepatitis Pulsed methylprednisolone 

分 类 号：R575.1[医药卫生—消化系统] R975[医药卫生—内科学]