抑癌基因P^(53)在肺癌中表达的意义  

Significance of Tumor Suppressor Gene P53 Expression in Primary Lung Cancer

作　　者：黄学胜[1,2] 刘锟[1,2] 王云杰 马乃绪[1,2] 王丽[1,2] 田德明[1,2] 

机构地区：[1]解放军91医院胸外科 [2]第四军医大学唐都医院胸外科

出　　处：《齐鲁肿瘤杂志》1997年第4期245-246,共2页

摘　　要：应用免疫组织化学技术—ＳＰ法，检测了１０６例原发性肺癌组织中Ｐ５３蛋白的异常表达，阳性表达率为５２．８％，其中鳞癌Ｐ５３蛋白阳性表达率为５２．８％，腺癌为４７．１％，未分化癌为６３．２％，其与组织学分型、分级及临床ＰＴＮＭ分期无关。Ｐ５３蛋白表达与肺腺癌有无肺门或纵隔淋巴结转移呈显著正相关（Ｐ＜０．０１），而在肺鳞癌和未分化癌中则未见．Ｐ５３蛋白表达与肺门或纵隔淋巴结转移间有相关性（Ｐ＞０．０５）。提示Ｐ５３抑癌基因突变在不同类型肺癌的演变过程中可能发挥不同的作用。The P53 expression in106 cases of primary lung cancer was studied with immunohistochemical technique.The results showed that the ratio of the P53 protein expression was 52.8 percent(56/106).The P53 protein expression was neither correlated with the histological type,nor the grade and the PTNM status.In pulmonary adenocarcinoma,the expression of P53 protein was correlated with lymph node metastasis(P<0.01).In squamous cell carcinoma and undifferentiated carcinoma ,the expression of P53 protein was not correlatied with lymph node metastasis(P>0.05).The results suggested that the mutation of P53 gene played different roles in the progress of adenocarcinoma,squamous cell carcinoma and undifferentiated carcinoma.

关 键 词：肺肿瘤 免疫组织化学 P53基因 抑癌基因 

分 类 号：R734.2[医药卫生—肿瘤]