急性脑梗塞患者红细胞免疫功能与变形能力的相关性研究  

Study of correlation between erythrocyte immune function change and erythrocyte deformation capacity for senile acute cerebral infarction

作　　者：毛德军[1] 于义英[1] 冯海燕[1] 薜银玲 

机构地区：[1]青岛市第二人民医院神经科

出　　处：《卒中与神经疾病》1997年第4期193-195,共3页Stroke and Nervous Diseases

摘　　要：检测了６９例老年人急性脑梗塞患者红细胞Ｃ３ｂ受体花环率（Ｅ－Ｃ３ｂＲＲ），免疫复合物花环率（Ｅ－ＩＣＲ）、血循环免疫复合物（ＣＩＣ），红细胞滤过指数（ＥＦＩ）的变化，并与４５例健康老年人检测结果进行比较。结果显示：脑梗塞患者ＥＦＩ明显高于对照组，差异有极显著性（Ｐ＜０．０１），Ｅ－Ｃ３ｂＲＲ明显低于对照组，ＣＩＣ明显高于对照组，差异均有显著性（Ｐ＜０．０５）。脑梗塞患者Ｅ－Ｃ３ｂＲＲ与ＥＦＩ呈显著负相关（ｒ＝－０．５０２，Ｐ＜０．０５），ＩＣＲ、ＣＩＣ与ＥＦＩ呈显著正相关（ｒ＝０．４９２，０．５９７，Ｐ＜０．０５），提示：老年急性脑梗塞患者红细胞免疫功能（ＲＣＩＡ）降低，可能是红细胞变形能力差、导致动脉硬化发生与发展的重要因素之一。In this study, the rate of erythrocyte C3b receptor rosette(EC3bRR), and immunocomplex rosette(EICR), the serum circulative immunocomplex(CIC) and the erythrocyte filtration index (EFI) were analysed in 69 cases of senile acute cerebral infarction and 45 healthy senile controls. The results ahowed that the level of EFI increased significantly in the patients compared with the controls (P<0.01), the EC3bRR of the patients was significantly lower than that of controls(P<0.05), amd the CIC of the patients was significantly higher than that of the controls (P<0.05)。 In the patients, there was a significant negative correlation between EC3bRR and EFI (r=-0.502, P<0.05),and EICR and CIC were strongly correlated to EFI(r=0.492, 0.597, P<0.05). This study suggests that for the semile acute cerebral infarcton patients , the decrease in erythrocyte immune function could be one of the important factors resulting in poor erythrocyte deformation capacity and leading to the occurance and development of arterial sclerosis.

关 键 词：脑梗塞 红细胞 免疫功能 变形能力 急性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]