GM_1对大鼠全脑缺血再灌注中海马线粒体钙和钙调素的影响  

Effect of GM1 on Mca.caM contents during cerebral ischemia and reperfusion

作　　者：徐仁四 黄怀钧 王风霞[1,2] 

机构地区：[1]同济医科大学 [2]湖北医科大学附属第二医院神经科

出　　处：《卒中与神经疾病》1997年第4期196-197,共2页Stroke and Nervous Diseases

摘　　要：用神经节苷脂（ＧＭ１）（１０ｍｇ／ｋｇ）处理器血管闭塞全脑缺血再灌注模型，观察缺血海马组织线粒体钙（ＭｉｔｏｃｈｏｎｄｒｉａＣａｌｃｉｕｍ、ＭＣａ）钙调素（Ｃａｌｍｏｄｕｌｉｎ，ＣａＭ）的含量变化及评价ＧＭ１对其变化的影响。结果表明。ＧＭ１能遏止缺血再灌注期ＭＣａ、ＣａＭ含量明显增高的变化，明显减轻缺血再灌注期的钙跨膜内流，具有肯定的脑保护作用。Applying cerebral ischemic model induced by 4vessel occlusion, the contents of mitochondria calaium (Mca), Calmodulin (caM)and the effect of manosidoltetrahexosylganglioside(GM1) were obseved. The results show that the ischemic reperfusion rat hippocampus Mca caM contents were significantly higher than the controls (P<0.01).After being treated with GM1,the changes above improved apparenty (P<0.01)and weren't significantly different as cmpared with control's (P>0.05)。The facts suggested that GM1 had effects of scavening the increase of Mca and caM contents on ischemic reperfusion brain damage.

关 键 词：神经节苷脂 线粒体钙 钙调素 脑缺血 

分 类 号：R743.31[医药卫生—神经病学与精神病学]