添加拉莫三嗪治疗难治性癫痫  

Lamotrigine as Add-on Drug in the Management of Intractable Epilepsy

作　　者：瞿治平[1] 俞丽云[1] 

机构地区：[1]上海医科大学附属华山医院神经科,上海200040

出　　处：《中国神经免疫学和神经病学杂志》1997年第4期199-202,共4页Chinese Journal of Neuroimmunology and Neurology

基　　金：上海多中心开放性研究组协作课题

摘　　要：采用保持原用抗病药物及剂量不变，添加拉莫三嗪（LTG）治疗161例难治性痛痛患者。以治疗前3个月的发作次数为基础，与治疗期间3个月内发作次数比较，结果显示：添加LTG后癫痫发作完全控制者12例，占7．45％；明显好转者69例，占42．8％。其中全身强直-阵挛发作者疗效最佳，其明显好转者为48．52％，部分性发作者中明显好转者为44％。Lennox－Gastaut综合征8例，明显好转者50％。该药副作用小，减量或停药后症状消失。Objective To evaluate efficiency and safety of lamotrigine (LTG) in patients with refractory epilepsy. Methods 161 patients with refractory epilepsy were treated by LTG as add-on therapy to the original antiepileptic drugs with dosages unchanged. Seizure counts in 3 months before and during LTG treatment were compared. Results 12 patients (7. 45% ) became seizure-free, significant decrease of seizure was obtained in patients with generalized tonicoclonic seizure(48. 52 % of which was significantly efficient). Significant efficiency was obtained in 44% of patients with partial seizures. 4 cases of Lennox-Gastaut syndrome were significant efficiency in total & cases. The adverse events of LTG were generally mild and would disappeared when the dose was decreased or the medication was discontinued.Conclusion Our findings showed LTG was effective, safe and well tolerated as add-on therapy for refractory epileptic seizures.

关 键 词：癫痫 拉莫三嗪 抗痫药 

分 类 号：R742.105[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]