格林-巴利综合征患者血清及脑脊液中GM1抗体及IgG指数检测  

The Detection of GM1-IgG Antibodies and IgG-Index in Serum and CSF in Patients with Guillain-Barre Syndrome

作　　者：闫晓波[1] 王维治[1] 

机构地区：[1]哈尔滨医科大学附属第二医院神经科,哈尔滨150086

出　　处：《中国神经免疫学和神经病学杂志》1997年第4期230-233,共4页Chinese Journal of Neuroimmunology and Neurology

摘　　要：检测了19例格林－巴利综合征（GBS）患者血清和脑脊液（CSF）中神经节苷酯1（GM１）－IgG抗体和lgG－指数，并与11例对照组比较。结果显示，GBS组GM1－IgG抗体滴度及IgG-指数均明显高于对照组，并在1例复发型GBS患者血清中检测出高水平GM1－IgG抗体。提示GM1可能是GBS相关抗原。GBS患者IgG-指数增高可能反映CSF中免疫活性细胞的激活。GM1－IgG抗体是否可作为GBS复发的标志尚待进一步验证。Objective in order to determine whether ganglioside GMI play a role in the pathogenesis of Guillian--Barre syndrome (GBS). Methods To test the anti--GMI--lgG level in serumand in CSF, and IgG--index by ELISA in 19 patients with GBS and in 11 control subjects.Results Elevated GMI levels was found in serum in 9 GBS patients (47. 3 % ) and in CSF in11 patients (57. 9 % ) respectively. IgG--Index was also elevated in 11 of 19 (57. 9 % ) GBS patients, moreover, very high levels of anti--GMI antibody was found in serum and CSF in apatient with relapsing GBS, whereas the anti--GMI antibody levels in serum and CSF as wellas IgG--index in control subjects were normal. Conclusion These data suggests that GMI isprobably an antigen associated with GBS. The high level of IgG--index may imply that theimmune reactive B cells were activated in CSF. The results of our study not only indicatethat the high level of anti--GMI can be used in clinical diagnosis of GBS, but also suggest anti--GMI antibody in CSF of GBS patients may take part in the mechanisms if immune damage. Whether the anti--GMI antibody can be the marker of relapsing GBS is worth to bestudied in future.

关 键 词：G-B综合征 神经节苷脂 IGG指数 脑脊液 

分 类 号：R745.43[医药卫生—神经病学与精神病学]