两种不同给药途径的足叶乙甙联合化疗对胃癌治疗作用的对比研究  

Comparative Study of Combined Chemotherapy with Etoposide From Two Different Methods on Carcinoma of Stomach

作　　者：孙红[1] 赵新汉[1] 薛颖[1] 

机构地区：[1]西安医科大学第一临床医学院肿瘤内科,710061

出　　处：《肿瘤防治研究》1997年第6期383-384,共2页Cancer Research on Prevention and Treatment

摘　　要：鬼臼乙叉甙Vp16是治疗胃癌的单一有效药物，本研究于1995年6月～1996年10月使用口服Vp16长程给药和静脉滴注Vp16两种不同给药途径并与阿霉素（ADR）、顺铂（C－DDP）组成联合化疗方案，对57例经病理组织学证实胃癌随机分组进行治疗，其有效率分别为46．4％及51．7％，且二组毒副反应相近，初步探讨了口服Vp16长程给药的可能性。Etoposide (VP16) is an unitary effective medicine to treat carcinoma of stomach.In order to probe the posibility of oral administration of it, between June, 1995 and Octobe, 1996, we adopted combined chemotherapy to treat 57 patients suffered from carcinoma of stomach. All of cases were confirmed by histopathology and the patients were randomly divided into two groups. The combined chemotherapy program wsa composed of etoposide, adriamycin and cisplatin. In it, etoposide was given by means of oral administration and intravenous drip. The effective rates of twogroups were 46. 4% and 51. 7% respectively and their toxic reaction were similar,So, we considered that etoposide could be given by orsl administration to treat carcinoma of stomach.

关 键 词：胃肿瘤 药物疗法 足叶乙甙 聚合化疗 

分 类 号：R735.205[医药卫生—肿瘤]