桂皮酸对PGCL3人肺癌细胞增殖和核仁组成区的影响  

The Effects of Cinnamic Acid on Proliferation and Nucleolar Organizer Regions of PGCL3 Human Lung Cancer Cell

作　　者：黄炜[1] 胡梅香 

机构地区：[1]广州医学院肿瘤研究所

出　　处：《实用癌症杂志》1997年第3期175-177,共3页The Practical Journal of Cancer

摘　　要：本研究的目的是探讨低毒性的食品调味剂桂皮酸对ＰＧＣＬ３人肺癌细胞的抑制作用。研究结果发现１ｍｍｏｌ／Ｌ和３ｍｍｏｌ／Ｌ桂皮酸能使ＰＧＣＬ３人肺癌细胞增殖受到明显抑制（Ｐ＜０．０５，Ｐ＜０．０１），增殖抑制率达４８．６％，同时发现细胞的核仁形成率明显下降，每个细胞平均核仁数由２．９２个降至１．６６和１．９６个（Ｐ＜０．０１），核仁内核仁组成区嗜银蛋白（ＡｇＮＯＲ）颗粒明显减少，每个细胞核仁内ＡｇＮＯＲ颗粒数由３９．２６±７．４９降至９．５４±４．６１和１９．６８±１０．４８（Ｐ＜０．００１和Ｐ＜０．０１）。表明桂皮酸是ＰＧＣＬ３人肺癌细胞有效的抑制剂，在抗癌作用方面具有潜在的应用价值。This study is intended to investigate the anticancer effects of the low toxic flavorings cinnamic acid on PGCL3 human lung cancer cell subine. The results show that cinnamic acid at concentrations of 1 mmol/L and 3 mmol/L can obviously inhibit proliferation of PGCL3 human lung cancer cells ( P < 0.05 to P < 0.01 ). The suppressive rate was up to 48.6%. At the same time, the nucleolar forming rate was markedly decline (the mean number of nucleolus in each cell from 2.92 reduced to 1.66 and 1.96 ) ( P < 0.01 ) and the number of particle of AgNOR in nucleolus markedly decrease from 39.26±7.49 reduced to 9.54±4.61 and 19.68±10.48 ( P <0.001 and P <0.01). These results showed that cinnamic acid is an efficient inhibitor of PGCL3 cell, and has potential use in cancer intervention.

关 键 词：肺肿瘤 癌细胞增殖 AGNOR染色 桂皮酸 

分 类 号：R734.205[医药卫生—肿瘤]