CT定量诊断脂肪肝的实验研究  

CT quantitative diagnosis in fatty liver: an experimental study

作　　者：赵虹[1] 李彬祥 张利中[1] 梁建芳[1] 

机构地区：[1]山西医科大学第一临床医院CT室

出　　处：《中华放射学杂志》1997年第12期836-839,共4页Chinese Journal of Radiology

摘　　要：目的：研究脂肪肝的脂肪含量与ＣＴ值之间的相关关系，以指导临床诊断和治疗。材料与方法：Ｗｉｓｔａｒ大鼠３５只，随机分为正常组５只，实验组３０只，制成脂肪肝模型。对正常组和随机抽取第一、二、三、四周末的实验组鼠各５只，行ＣＴ扫描，测得全肝的ＣＴ值。取左、中、右叶肝组织各一块，制成光镜切片，用显微图像分析仪测得肝中脂滴的体积占整个肝组织的百分比（Ｖｖ值）。结果：在ＣＴ值与Ｖｖ值之间存在有意义的线性负向相关关系（γ＝－０．９５０，ｔ＝１２．９０，Ｐ＜０．００１）。结论：利用ＣＴ值与Ｖｖ值之间的线性相关关系，通过ＣＴ监测，不仅可对脂肪肝的程度、范围和脂肪含量做出估计，而且可替代肝活检定量法。在脂肪肝的治疗过程中，用该技术追踪随访疗效，不失为一种重要的手段。Purpose: To evaluate the relation between liver fat content and CT value in animal experiment for the diagnosis and treatment of fatty liver in clinical practice. Materials and methods: Fatty liver model was established in 30 Wistar rats (experimental group), 5 rats were used as the control group. The 5 rats of the control group and 5 rats randomly chosen from experimental group at the first, second, third, and the fourth weekends, were measured for the CT number of total liver. Three pieces of liver specimen from each rats were removed from left, central and right lobes for histologic examination. The ratio of liver fat content to liver volume (Vv value) was measured by microscopic image pattern analyzer. Results: Significant linear negative correlation (r=-0.950, t=12.90, P<0.001) was found between CT and Vv values. Conclusion: Using CT monitoring, the degree and amount of liver fat could be assessed and liver biopsy obviated in the diagnosis and follow up during treatment of fatty liver.

关 键 词：脂肪肝 CT 诊断 实验研究 

分 类 号：R575.504[医药卫生—消化系统] R816.5[医药卫生—内科学]