血管内皮生长因子及其受体与非小细胞肺癌血管新生  

Vascular endothelial growth factor and its receptor involved in non-small cell lung cancer angiogenesis

作　　者：徐益明[1] 金美玲[1] 

机构地区：[1]复旦大学附属中山医院呼吸内科,上海200032

出　　处：《国际呼吸杂志》2008年第18期1132-1135,共4页International Journal of Respiration

摘　　要：肿瘤生长和转移都依赖于新生血管的形成。血管内皮生长因子（vascular endothelial growth factor，VEGF）是血管新生最重要的诱导因子。不同VEGF及其受体的亚型功能相异。目前，对VEGF信号转导通路机制的研究取得了很大进展，通过阻断VEGF的某些环节来抑制血管新生的靶向治疗成为非小细胞肺癌的治疗热点。Neoangiogenesis is crucial for sustained turnout growth and metastasis. Vascular endothelial growth factor（VEGF） plays the most role in regulation of neoangiogenesis. Moreover, members of the VEGF family are involved in different biological processes. Much progress has been achieved in elucidating its signal transduction. It is now well established that VEGF axis represents an important target for antitumor especially in therapy of non-small cell lung cancer.

关 键 词：血管内皮生长因子 受体 非小细胞肺癌 血管生成抑制剂 

分 类 号：R734[医药卫生—肿瘤]