类泛素蛋白FAT10与肝细胞癌  

Ubiquitin-related protein FATIO and hepatocellular carcinoma

作　　者：刘天德[1] 余新(综述)[1] 邵江华(审校)[1] 

机构地区：[1]南昌大学第二附属医院肝胆外科,330006

出　　处：《国际肿瘤学杂志》2008年第9期700-704,共5页Journal of International Oncology

基　　金：基金项目：2008年度教育部科学技术研究重点项目（208070）

摘　　要：泛素／类泛素系统是体内细胞蛋白降解的一个重要途径，大量研究表明该系统功能失调将导致癌基因和抑癌基因表达的异常，在肿瘤的发生发展中起重要作用。FAT10是近年发现的类泛素蛋白家族成员，FAT10在肝细胞癌等恶性肿瘤中表达水平异常增高，很有可能成为一个新的肝细胞癌形成前标记物。Ubiqitin/ubiqitin-related system is a significant pathway of protein degradation in vivo. Plenty of researches suggest that the functional disorder of this system will lead to the expression abnormality of oncogene and anti-oncogene. It plays an important role in the development of tumors. FATIO is one of the members of ubiqitin-related proteins,which is discovered in recent years. The present research reveals that the expression of FATIO is highly upregulated in malignant tumors, especially in hepatoeellular carcinoma. FATIO may be become an epigenetic marker for liver preneoplasia.

关 键 词：肝肿瘤 泛素 FAT10 

分 类 号：R735.7[医药卫生—肿瘤]