低剂量顺铂联合5-氟尿嘧啶周疗同步放疗治疗中晚期宫颈癌  

Concurrent radiotherapy and weekly chemotherapy with low-dose cisplatin and 5-fluorouracil for advanced cervical cancer

作　　者：贾惠[1] 朱兆峰[1] 苏培英[1] 

机构地区：[1]泰安市肿瘤防治院妇瘤科,271000

出　　处：《国际肿瘤学杂志》2008年第9期718-720,共3页Journal of International Oncology

摘　　要：目的评价低剂量顺铂（DDP）＋5-氟尿嘧啶（5-FU）周疗同步放疗治疗中晚期宫颈癌的疗效和不良反应。方法73例中晚期宫颈癌患者随机分为化放组（37例）和单放组（36例）。化放组放疗同期每周接受1次DDP 40mg＋5-FU 500mg化疗，连用6～7周；单放组行单纯放疗。两组放疗均采用常规分割，总剂量50Gy。结果化放组与单放组总有效率、3年生存率、局部复发率、远处转移率分别为97．30％和77．78％、89．19％和66．67％、8．11％和30．56％、10．81％和33．33％，两组对比差异均有统计学意义（P〈0．05），骨髓抑制及消化道反应发生率化放组均高于单放组，多为Ⅰ、Ⅱ级。结论低剂量DDP＋5-Fu周疗同步放疗治疗中晚期宫颈癌可显著提高患者的局部控制率和生存率，不良反应轻。Objective To evaluate the therapeutic efficiency and side effect of concurrent radiotherapy and weekly chemotherapy with low-dose cisplatin（DDP） and 5-fluorouraeil（5-FU） for advanced cervical cancer. Methods 73 patients with advanced cervical cancer were randomized into two groups：37 cases in the chemo-radiotherapy group received radiotherapy combined with DDP 40 mg and 5-FU 500 mg weekly for 6-7 weeks. 36 cases in the only radiotherapy group received radiotherapy alone. Radiotherapy was given with conventional fraction,the total tumor dose was 50 Gy. Results The rate of overall response and three-year survival and local recurrent and distant metastasis for the chemo-radiotherapy group and the only radiotherapy group were 97.30% , 89. 19% , 8. 11% and 10. 81% , and those for the only radiotherapy group were 77. 78% , 66. 67% , 30. 56% and 33.33 %. The difference of the four groups was statistically significant （ P〈0.05）. The rate of bone marrow inhibition and reaction of digestive tract in chemo-radiotherapy group were higher than those in simple radiotherapy group,but most reactions were grade l and grade 2, without statistically significant diferenee between two groups. Conclusion Concurrent radiotherapy and weekly chemotherapy with low-dose cisplatin and 5-fluorouracil for advanced cervical cancer can significantly improve local control rate and survival rate, and have slight side effects.

关 键 词：宫颈肿瘤 综合疗法 

分 类 号：R737.33[医药卫生—肿瘤]