促甲状腺激素受体及碘钠泵在人甲状腺癌中的表达及临床意义  

EXPRESSIONS AND CLINICAL SIGNIFICANCE OF THYROID STIMULATING HORMONE RECEPTOR AND Na^+-I^- SYMPORTER IN HUMAN THYROID CARCINOMA

作　　者：刘春萍[1] 楚慧敏[1] 明洁[1] 潘华雄[1] 黄韬[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院乳腺甲状腺外科,武汉430022

出　　处：《解剖学报》2008年第5期756-759,共4页Acta Anatomica Sinica

摘　　要：目的研究促甲状腺激素受体(TSHR)、碘钠泵(NIS)在甲状腺癌中的表达,探讨其在人甲状腺癌治疗中的作用。方法采用免疫组织化学SABC法,检测TSHR、NIS在45例人正常甲状腺组织、45例乳头状甲状腺癌及21例未分化甲状腺癌中的表达。结果TSHR及NIS在人正常甲状腺组织的表达均高于其在乳头状甲状腺癌和未分化甲状腺癌中的表达。在人正常甲状腺组织,TSHR和NIS蛋白均定位于滤泡上皮细胞膜上;在乳头状甲状腺癌组织,TSHR蛋白定位于细胞膜和细胞质中,NIS蛋白仅在细胞质中有阳性表达;在未分化甲状腺癌,TSHR和NIS均定位于细胞质。结论TSHR、NIS的定位及表达水平与甲状腺癌的分化程度密切相关,可能成为预测甲状腺癌促甲状腺激素抑制治疗及131I治疗是否有效的指标。Objective To investigate the expressions of thyroid stimulating hormone receptor （TSHR） and Na^＋-I- symporter （NIS） in thyroid carcinoma and their role in the process of treatment of thyroid carcinoma. Methods The expressions of TSHR and NIS in 45 normal thyroid tissues, 45 papillary thyroid carcinoma （PTC） tissues and 21 anaplastic thyroid carcinoma （ATC） tissues were detected by immunohistochemical SABC technique respectively. Results The expressions of TSHR and NIS in normal thyroid tissues were higher than those in PTC tissues and ATC tissues. TSHR was all expressed on the membrane of follicular epithelial cells of normal thyroid tissues, which were all expressed in the cytoplasm of ATC cells. In PTC the percentage of expressions in cytomembrane and cytoplasm were 71.1% and 15.6% respectively. NIS was all expressed on the membrane of follicular epithelial cells of normal thyroid tissues, which were all expressed in the cytoplasm of PTC cells and ATC cells. Conclusion The expression location and the expression level of TSHR and NIS are closely related with the differentiation degrees of thyroid carcinoma, which may become the effect indication of TSH suppression therapy and radioiodine therapy.

关 键 词：促甲状腺激素受体 碘钠泵 乳头状甲状腺癌 未分化甲状腺癌 免疫组织化学 人 

分 类 号：R736.1[医药卫生—肿瘤]