儿童孤独症临床分析及其与GRPR基因多态性的关系  

The clinical analysis and gastrin-releasing peptide receptor gene polymorphism in 59 cases children of autism

作　　者：陈艳妮[1,2] 王珏[1] 黄燕霞[2] 邵冬冬[2] 

机构地区：[1]西安交通大学生命工程与技术学院康复科学与技术研究中心,西安710049 [2]西安市儿童医院儿童保健科

出　　处：《中国康复医学杂志》2008年第9期810-811,814,共3页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:分析儿童孤独症接受康复治疗情况、社会因素及与遗传的关系。方法:对59例儿童孤独症进行了发现年龄、诊断年龄、接受康复治疗年龄、药物治疗史、ABC量表、社会适应量表、患儿家庭经济状况及胃泌素释放肽受体基因(GRPR)第二外显子多态性的测定。结果:儿童孤独症的发现年龄、确诊年龄及治疗年龄间差异有显著性(P<0.001);儿童ABC行为量表的交往因子、运动因子与发现年龄有关(rs=-0.38,P<0.05;rs=-0.27,P<0.05);GRPR第二外显子基因型TT、CC间和CC、CT间社会行为量表的粗分差异有显著性(P<0.01)。结论:儿童孤独症存在确诊和康复治疗不及时的现象;早发现与患儿的运动能力,特别是交往能力相关;GRPR基因第二外显子多态性与社会行为和适应能力有关。Objective：To analysis relationship among social factors,clinical features and genetics in children of autism.Method：Fifty-nine cases of autism children were observed for age of discovery,diagnose,treat time,family economy,mother＇s health in gestation and birth,family history,ABC,CBCL,FES and gastrin-releasing peptide receptor（GRPR） gene.Result：The differences among the age of finding,diagnosis and treatment were significant（P〈0.001） .The relationship between the finding age and R or B factor of ABC was significant（rs=-0.38,P〈0.05;rs=-0.29,P〈0.05） .There were significant differences on the round scores of CBCL between genotype groups of TT,CC and CC,CT（P〈0.01） .Conclusion：In children autism the treating age was delayed significantly,compared with age of discovery and diagnose.Early finding was related to children＇s communication and motor behavior.GRPR gene polymorphism was related to the ability of social behavior and accommodation.

关 键 词：儿童 孤独症 社会因素 临床分析 胃泌素释放肽受体基因 

分 类 号：R749.94[医药卫生—神经病学与精神病学]