Bcl-2和Bax的表达与乳腺癌组织学分级及预后的关系  

The relationship between expression of bcl-2,bax gene and histologic grade,prognosis of breast cancer

作　　者：曲文志[1] 涂巍[1] 于作夫[1] 赵曼[1] 金光华[1] 王勤勇[1] 

机构地区：[1]中国医科大学附属第四医院乳腺外科,辽宁沈阳110032

出　　处：《现代肿瘤医学》2008年第10期1692-1694,共3页Journal of Modern Oncology

摘　　要：目的:探讨bcl-2和bax基因在乳腺癌中的表达与乳腺癌组织学分级及预后的关系。方法:应用SP免疫组化染色方法,检测40例乳腺癌组织中bcl-2、bax的表达情况。结果:组织学Ⅰ级+Ⅱ级乳腺癌中bcl-2蛋白阳性表达率与组织学Ⅲ级乳腺癌中bcl-2蛋白阳性表达率有显著差异(P<0.01),Ⅰ+Ⅱ级组bax蛋白阳性表达率与Ⅲ级组bax蛋白阳性率表达无显著差异(P>0.05),Ⅰ级+Ⅱ级组bcl-2高表达和bax低表达(bcl-2/bax≥1)与Ⅲ级组bcl-2高表达和bax低表达(bcl-2/bax≥1)有显著差异(P<0.01)。10年以上存活组中bcl-2阳性表达率与10年以下存活组有显著差异(P<0.01);10年以上存活组bax阳性表达率与10年以下存活组有显著差异(P<0.05);10年以上存活组bcl-2高表达和bax低表达(bcl-2/bax≥1)与10年以下存活组bcl-2高表达和bax低表达(bcl-2/bax≥1)有显著差异(P<0.05)。结论:bcl-2和bax比值与乳腺癌组织学分级、预后关系密切,bcl-2高表达和bax低表达的乳腺癌患者组织学分级好,预后好。Objective：To evaluate the correlation between expression of bcl -2 and bax gene and histologic grade, prognosis of breast cancer. Methods： Immunohistochemical technique was used to detect the expression of bel - 2 and bax gene in 40 cases of breast cancer. Results： There was a remarkable difference of the positive rate of bel - 2 between the group of grade Ⅰ , grade Ⅱ and the group of grade Ⅲ（ P 〈 0.01 ）, no remarkable difference of the positive rate of bax between the group of grade Ⅰ , grade Ⅱ and the group of grade Ⅲ （ P 〉 0. 05 ） , There was a remarkable difference of high bcl -2 expression and low bax expression（ bcl -2/bax≥1 ）between the group of grade Ⅰ ,grade Ⅱ and the group of grade Ⅲ （ P 〈 0.01 ）. There was a remarkable difference of the positive rate of bel - 2 between the group that lived over 10 years and the group that lived for less than 10 years （ P 〈 0. 01 ） ; There was a remarkable difference of the positive rate of bax between the group that lived over 10 years and the group that lived for less than 10 years （P 〈 0.05 ） ; There was a remarkable difference of high bel -2 expression and low bax expression （bcl -2Y bax ≥ 1 ）between the group that lived over 10 years and the group that lived for less than 10 years（ P 〈 0.05 ）. Conclusion： The expression of be1 -2, bax have a closed relation with histologic grade and prognosis of breast cancer, the patient with over expression of bcl - 2 or low expression of bax has better histologie grade and better prognosis.

关 键 词：BCL-2 BAX 乳腺癌 组织学分级 预后 

分 类 号：R737.9[医药卫生—肿瘤]