前列腺癌中BAG-1、bcl-2及bax的表达及意义  

Expression and significance of BAG-1,bcl-2 and bax in prostate cancer

作　　者：孟庆超[1] 李静梅[1] 仇让学[1] 王禾[2] 王映梅[2] 马福成[2] 

机构地区：[1]解放军第92医院泌尿外科,福建南平353000 [2]第四军医大学西京医院泌尿外科,陕西西安710032

出　　处：《现代肿瘤医学》2008年第10期1729-1732,共4页Journal of Modern Oncology

摘　　要：目的:检测凋亡抑制因子BAG-1在前列腺癌组织(PCa)中的表达,探讨其与前列腺癌发生发展的关系及其与bcl-2和bax表达的关系。方法:采用免疫组织化学染色法检测BAG-1、bcl-2、bax在10例前列腺增生组织(BPH)、45例PCa组织中的表达。结果:BAG-1在BPH、PCa中的阳性表达率分别为20%(2/10)、91.1%(41/45)。PCa中BAG-1表达水平明显高于BPH(P<0.05),且在癌组织中与肿瘤临床分期(P<0.01)、病理分级(P<0.01)呈正相关。BAG-1与bcl-2在PCa中的表达正相关(P<0.05)。BAG-1与bax在PCa中的表达也呈正相关(P<0.05)。结论:BAG-1基因可能通过抑制凋亡在PCa的发生发展中发挥重要作用,且其表达与bcl-2。Objective ：To investigate the expression and significance of an inhibitor gene of apoptosis, BAG - 1 ,in prostate cancer （PCa）, and its relationship with the expression of bcl -2, bax. Methods：The expression of BAG - 1, bcl -2 and bax in sample of 10 BPH and 45 PCa were examined by immunohistochemical stain. Results：The positive rate for BPH and PCa were 20% （2/10） ,91.1% （41/45） much higher than in BPH（P 〈0.05） ,and it was related respectively . The expression level of BAG - 1 in PCa was positively with clinical stage （ P 〈 0.01 ） and pathological grade（ P 〈 0.01 ）of PCa. BAG- 1 positive cases were strongly associated with bcl- 2 expression （P 〈 0.05 ） and bax expression （P 〈 0.05 ）. Conclusion： BAG - 1, alone or in cooperation with bcl -2 and bax, may play an important role in the onset and progression of PCa by the anti - apoptosis pathway.

关 键 词：前列腺肿瘤 凋亡 BAG-1 BCL-2 BAX 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]