亚砷酸联合全反式维甲酸治疗急性早幼粒细胞白血病16例疗效观察  

Arsenic trioxide(As_2O_3) combined with all-trans retinoic acid (ATRA) therapy for patients with acute promyelocytic leukemia (APL):a report of 16 cases

作　　者：朱贵华[1] 林圣云[1] 李秀梅[2] 韩秀华[2] 庄万传[2] 胡致平[1] 

机构地区：[1]浙江中医药大学附属第一医院血液科,浙江杭州310006 [2]连云港市第二人民医院血液科,江苏连云港222023

出　　处：《现代肿瘤医学》2008年第10期1762-1763,共2页Journal of Modern Oncology

摘　　要：目的:观察亚砷酸(As2O3)与全反式维甲酸(ATRA)联合治疗初发急性早幼粒细胞白血病(APL)的疗效和不良反应。方法:As2O3联合ATRA治疗初治APL患者16例,As2O30.1%注射液10ml加入5%葡萄糖溶液500ml静脉点滴,持续4h,1次/d;ATRA40-60mg/d,分2次口服,观察完全缓解(CR)率,获得CR所需时间、不良反应。结果:15例患者获得CR,CR率93.8%,获得缓解时间(27.3±3.6)d,没有发现明显的不良反应。结论:As2O3联合ATRA治疗初发APL患者疗效好,能缩短CR的时间,长期CR时间需要进一步观察。Objective： To observe the efficacy and side effects of arsenic trioxide combined with all - trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia（APL）. Methods：Sixteen newly diagnosed APL patients of whom 7 were males,9 females and median age 33 years entered into the study. They were treated with 0. 1% As2O3 10ml （10rag）/d combined with ATRA 20 - 30mg bid, until complete remission （CR）. The doses were adjusted according to white blood cell counts, occurrence of RA syndrome and the status of liver function. CR rate, time of reaching clinical remission and side effects were observed. Results： 15 （93.8%） patients achieved CR, one patient died 3 days after the treatment due to encranial hemorrhage. The average time for achieving CR was （27.3 ± 3.6） d, no significant side effect was found. Conclusion： The efficacy in the patients with de novo APL who are treated with As203 and all -trans retinoic acid is high, and the therapy can lessen the time of reaching CR. Long term effect needs further observation.

关 键 词：白血病 早幼粒细胞 急性 亚砷酸 维甲酸 

分 类 号：R733.71[医药卫生—肿瘤]