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出 处:《实用口腔医学杂志》2008年第5期741-743,共3页Journal of Practical Stomatology
基 金:2005年河北省科委指导基金项目(编号:05276102)
摘 要:目的:探讨布洛芬局部用药新剂型的研制及其对慢性牙周炎的临床治疗效果。方法:采用PLGA(聚乳酸-乙醇酸共聚物)作为缓释辅料制备布洛芬缓释凝胶。运用紫外分光光度法检测布洛芬缓释凝胶的体外释放度。临床选择慢性牙周炎患者30例共60颗患牙作为研究对象,每例患者保证口腔内有2颗病情相近的患牙用作自身对照,分别分入实验组和对照组。实验组患牙在进行牙周洁刮治及根面平整后向牙周袋内注入实验药物,每周1次,共2次;而对照组患牙仅进行牙周洁刮治及根面平整。分别于基线、治疗后第2周及第4周观察患牙局部的临床症状、龈沟出血指数、牙周袋探诊深度及附着丧失。2组间对比并进行统计学处理。结果:实验组与对照组在治疗后各项临床指标差异具有显著性(P<0.05)。结论:布洛芬缓释凝胶能有效改善慢性牙周炎的临床症状,控制牙周炎症,减少组织破坏,具有很好的临床实用意义。Objective:To explore the feasibility of sustained-release ibuprofen gel as a new local drug and its efficacy in the treatment of chronic periodontitis. Methods: Sustained-release ibuprofen gel was manufactured with PLGA as sustained-release adjuvant. Its release in vitro was tested by UV-spectrophotometer. 60 teeth from 30 chronic periodontitis patients were chosen. Each patient had two teeth which were similar. The two teeth of every patient were divided into experiment group and control group. After scaling and root planning the sustained-release ibuprofen gel was injected into the pocket in the experiment group every week, two times in all. While those in the control group only had scaling and root planning. The local symptoms, sulcus bleeding index (SBI), probing depth (PD) and attachment level (AL) of the two groups were observed in the second and fourth week after treatment. Results obtained from the two groups were compared. Results: There were significant differences in each clinical index between the experiment group and the control group ( P 〈 0.05 ). Conclusion : Sustained-release ibuprofen gel is effective in easing chronic periodontitis, controlling inflammation and reducing damaged tissues. It has a very practical significance.
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