VEGF-C和TSP-1在卵巢上皮癌中的表达及意义  

Expression and significance of VEGF-C and TSP-1 in epithelial ovarian carcinoma

作　　者：叶璐[1] 冯亦军[1] 马奔[2] 李书华[3] 

机构地区：[1]广东省第二人民医院妇科,广州510317 [2]广州市第一人民医院妇产科 [3]广州医学院病理教研室

出　　处：《中华临床医师杂志（电子版）》2008年第10期29-31,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的检测人卵巢上皮癌组织中血管内皮生长因子C(VEGF-C)、凝血酶敏感蛋白1(TSP-1)表达及微血管密度(MVD),探讨VEGF-C、TSP-1与卵巢癌临床病理特征之间的关系。方法以免疫组化法检测卵巢上皮癌50例以及正常卵巢组织20例石蜡标本中VEGF-C、TSP-1表达及MVD。结果卵巢上皮癌中VEGF-C表达及MVD均明显高于正常卵巢组织(P<0.05),TSP-1表达低于正常卵巢组织(P<0.05);卵巢上皮癌组织中,VEGF-C表达及MVD随国际妇产科联盟(FIGO)分期的进展而增高(P<0.05),TSP-1表达随FIGO分期的进展而降低(P<0.05)。结论卵巢上皮癌组织中VEGF-C过表达及TSP-1低表达与肿瘤血管生成及侵袭进展密切相关。Objective To examine expression of vascular endothelial growth factor C （VEGF-C）, thrombospondin-I （TSP-1） and microvessels density （MVD） in human epithelial ovarian carcinoma tissue. Try to illuminate the relationship between VEGF-C, TSP-1 and the clinical pathological features of ovarian carcinoma. Methods Slices of 50 cases definitely diagnosed as epithelial ovarian carcinoma and 20 normal cases were collected. VEGF-C,TSP-1 expression and MVD in slices were examined by immunohistochemistry staining. Results 1. VEGF-C expression and MVD in epithelial ovarian carcinoma were higher than those in normal ovarian tissue （P 〈0. 05）, TSP-1 expression were lower than those in normal ovarian tissue （P 〈 0. 05 ） ;2. In epithelial ovarian carcinoma tissue, VEGF-C expression and MVD increasing according to progression of the FIGO phase but TSP-1 expression decreasing according to progression of the FIGO phase. Conclusions Over expression of VEGF-C and low expression of TSP-1 in epithelial ovarian carcinoma tissue may play roles in angiogenesis,invasion and metastasis of the tumor.

关 键 词：卵巢肿瘤 血管内皮生长困子C 凝血酶敏感蛋白1 微血管密度 

分 类 号：R737.31[医药卫生—肿瘤] R711.71[医药卫生—临床医学]