血管黏附分子在大肠癌组织中的表达及意义  

Expression of vascular cell adhesion molecules-1 and its role in development of colorectal carcinoma

作　　者：赖晓嵘[1] 童华生[2] 何美蓉[2] 武金宝[2] 蔡洁毅 王启仪[1] 

机构地区：[1]广东省人民医院,广东广州510120 [2]南方医科大学南方医院 [3]广东省药学院第一附属医院

出　　处：《山东医药》2008年第26期1-2,共2页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30171053)

摘　　要：目的探讨血管黏附分子(VCAM-1)在大肠癌发生、发展中的作用。方法用免疫组化SABC法检测65例大肠癌、16例大肠息肉和4例癌旁组织中VCAM-1的表达,酶联免疫吸附试验检测20例健康人、40例大肠癌患者外周血可溶性VCAM-1(sVCAM-1)水平,分析VCAM-1表达与大肠癌病理特征的关系。结果大肠癌组织中VCAM-1阳性率明显高于大肠息肉和癌旁组织(P均<0.01),VCAM-1表达与大肠癌的侵袭深度及淋巴结转移相关。大肠癌患者外周血清sVCAM-1水平高于健康人(P<0.01),其中有淋巴结转移者明显高于无淋巴结转移者(P<0.01)。结论VCAM-1可促进大肠癌的发生、发展;sVCAM-1有望成为大肠癌早期诊断及判断转移的指标。Objective To investigate the expression of the vascular cell adhesion molecules-1 （ VCAM-1 ） and soluble VCAM-1 （ sVCAM-1 ） in colorectal carcinoma and its role in the progression. Methods The expression of VCAM-1 was detected by immunohistochemistry in 65 cases of colorectal carcinoma, 16 colon polypus and 4 transitional tissues. The level of sVCAM-1 in the blood samples of 20 controls and 40 colorectal tumor cases was measured by using ELISA. The relationship between VCAM-1 expression and colorectal carcinoma pathology was evaluated. Results The Positive rate of VCAM- 1 was higher in colorectal carcinoma than that in colon adenoma and transition tissues and which was associated with the tumor invasiveness and lymphatic metastasis. The level of sVCAM-1 in colorectal carcinoma was higher than that in the controls （ P 〈 0.01 ）, and which was related to lymphatic metastasis （ P 〈 0.01 ）. Conclusion VCAM-1 may play an important role in the development and progression of colorectal carcinoma, and sVCAM-1 may offer a promise for the early diagnosis and metastasis as a bio-marker.

关 键 词：大肠肿瘤 血管黏附分子 转移 

分 类 号：R735.3[医药卫生—肿瘤]