腹腔热灌注联合全身化疗在恶性腹腔积液控制中的近期疗效  

Short-term effects of combinant intraperitoneal hyperthermal chemotherapy with general chemotherapy in malignant ascites

作　　者：胡宗兰[1] 曹军丽[1] 付占昭[1] 顾涛[1] 程少会[1] 华海侠[1] 杨森[1] 张丽娇[1] 杨雁鸿[1] 董立新[1] 

机构地区：[1]河北医科大学附属秦皇岛第一医院肿瘤科,066000

出　　处：《中华全科医师杂志》2008年第10期701-702,共2页Chinese Journal of General Practitioners

摘　　要：选择具有中至大量恶性腹腔积液的晚期肿瘤患者61例，采用信封随机法分为腹腔热灌注联合全身化疗31例（治疗组）和全身化疗30例（对照组），观察两组的近期疗效及不良反应差异。结果示治疗组的完全缓解率、部分缓解率及临床受益率均高于对照组（分别为38．7％比13．3％，41．9％比16．7％，90．3％比66．7％），差异具有统计学意义（P值分别为0．024、0．031、0．024），两组的严重不良反应差异无统计学意义（P=0．445）。提示腹腔热灌注联合全身化疗能有效地控制恶性腹腔积液，且不良反应可耐受。Sixty-one patients with moderate to severe malignant ascites were enrolled and randomly assigned to receive intraperitoneal hyperthermal chemotherapy ＋ intravenous chemical injection （ treatment group; n = 31 ） or routine intravenous chemical injection （ control group; n = 30）. Short-term response and reverse effects were observed. Our results indicated that the complete remission rate, part remission rate, and clinical benefit rate in the treatment group was significantly higher than those in the control group （38.71% vs 13.33% ,41.94% vs 16.67% , and 90.32% vs 66.67% , respectively）. No difference in reverse effects was found between the two groups. Our data suggest that intraperitoneal hyperthermal chemotherapy plus general chemotherapy may effectively control the malignant ascites, and the reverse effects might be well tolerated.

关 键 词：化学疗法 肿瘤 局部灌注 腹腔积液 

分 类 号：R730[医药卫生—肿瘤]