分化型甲状腺癌手术联合^(131)Ⅰ清甲治疗后复发与乏氧诱导因子-lα表达的关系  

Relationship between HIF-lα expression and recurrence of differentiated thyroid carcinoma after complete thyroidectomy combined with ^(131)Ⅰ treatment

作　　者：李丹丹[1] 赵劼[1] 孙辉[1] 温强[1] 高识[1] 马庆杰[1] 赵国庆[1] 

机构地区：[1]吉林大学中日联谊医院核医学科,吉林长春130033

出　　处：《吉林大学学报（医学版）》2008年第5期867-870,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅科研基金资助课题(200705277)

摘　　要：目的:研究分化型甲状腺癌手术联合131I清除剩余甲状腺(清甲)治疗后复发与乏氧诱导因子-1α(HIF-1α)表达的相关性,探讨HIF-1α对治疗后复发的可能机制。方法:依据甲状腺球蛋白(Tg)、甲状腺球蛋白抗体(TgAb)、B超、X线及全身131I显像的复发判定标准,观察分析173例分化型甲状腺癌手术联合131I清甲治疗成功后3年复发率,将复发病例作为复发组;随机选取相同数量未复发病例作为无复发组。采用免疫组织化学法和RT-PCR技术检测复发组和无复发组患者癌组织中HIF-1α阳性细胞率和HIF-1α基因表达水平。结果:分化型甲状腺癌手术联合131I清甲治疗成功后3年内复发率为5.20%(9/173)。其中乳头状癌复发率为4.90%(5/102),滤泡状癌复发率为5.63%(4/71),2组间比较差异无显著性(P>0.05)。复发组乳头状癌和滤泡状癌组织HIF-1α阳性细胞率和HIF-1α基因表达水平明显高于无复发组(P<0.05)。结论:分化型甲状腺癌手术联合131I清甲治疗成功后仍有少数患者复发,其机制之一可能与癌组织中HIF-1α表达水平明显增高有关。Objective To research the relationship between hypoxia-inducible factor-1 alpha （HIF-1α） expression and the recurrence of differentiated thyroid carcinoma （DTC） after complete thyroidectomy combined with ^131Ⅰ treatment, and explore its possible mechanism of recurrence. Methods The recurrence rate of 173 cases of DTC after complete thyroidectomy within 3 years was analyzed, according to the follow-up detecting data of Tg, TgAb, B-mode ultrasonography, X-ray scanning and global ^131Ⅰ imaging, the cases of recurrence were used as recurrence group, the same number cases without recurrence as control group which were chosen randomly. The HIF-1α expressions in recurrence cancer tissues and un-recurrence cancer tissues were detected with immunohistochemical staining and RT-PCR technique. Results The 3-year recurrence rate after thyroidectomy was 5.20% （9/173）, among them, the recurrence rate of papillary carcinoma was 4.90% （5/102）, while the recurrence rate of follicle carcinoma was 5.63% （4/71）, there was no significant difference between two groups （P〉0.05）. The HIF-1α expression levels in recurrence tissues of papillary carcinoma and follicle carcinoma were significantly higher than those in unrecurrence tissues （P〈0.05）. Oonolusion Several recurrence eases can be still found in DTC cases after complete thyroidectomy combined with ^131Ⅰ treatment, one of its mechanisms may be related to significant increase of the HIF-1α expression level in cancer tissue.

关 键 词：分化型甲状腺肿瘤 ^131Ⅰ治疗 复发 乏氧诱导因子-1Α 

分 类 号：R736.1[医药卫生—肿瘤]