齐拉西酮与利培酮治疗精神分裂症对照研究的Meta分析  

Meta-analysis of clinical effects of ziprasidone and risperidone in the treatment of schizophrenia

作　　者：任志斌[1,2] 童振华[1,2] 金卫东[1,2] 王鹤秋[1,2] 

机构地区：[1]浙江省立同德医院 [2]浙江省精神卫生中心

出　　处：《精神医学杂志》2008年第5期350-352,共3页Journal of Psychiatry

摘　　要：目的评价齐拉西酮与利培酮治疗精神分裂症的疗效和安全性以及与对照组之间的差异。方法应用循证医学方法对符合标准的15项研究进行分析,评价齐拉西酮与与利培酮治疗精神分裂症的有效率、痊愈率以及副作用的差异。结果齐拉西酮组与利培酮治疗精神分裂症的有效率以及痊愈率均没有显著性差异(P>0.05),但是利培酮的副作用,特别是EPS显著高于齐拉西酮(P<0.01)。结论齐拉西酮和利培酮都是治疗精神分裂症良好的药物,但是它们的副作用存在差异。Objective To assess the difference of efficacy and safety between ziprasidone and risperidone in the treatment of schizophrenia . Methods Fifteen studies meeting the criteria were analyzed by based--evidence medicine, the difference in efficacy rate, full remission rate and side effcts were compared. Results No significant differences of effective rate and full remission rate were found between ziprasidone and rispendone. （P〉 0.05）The incidence of side effects, especially EPS was significantly higher in risperidone than that of ziprasione（P〈0.01） 1. Conclusion Both ziprasidone and risperidone are better drugs for treating patients with schizophrenia , but different in side effects.

关 键 词：齐拉西酮 利培酮 精神分裂症 META分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]