XELOX替代OFL完成12例胃结肠癌化疗报道  

XELOX Is Safe and Effective Chemotherapy Replacing OFL in the Treatment of Advanced Gastric Cancer or Colon Carcinoma Patients

作　　者：杜剑平[1] 胡冰[1] 陈曼萍[1] 何义富[1] 

机构地区：[1]安徽医科大学附属省立医院肿瘤内科,安徽合肥230001

出　　处：《肿瘤基础与临床》2008年第5期415-416,共2页journal of basic and clinical oncology

摘　　要：目的完成因OFL(奥沙利铂+CF+5-Fu)毒副反应而无法进行下去的13例胃癌或结肠癌患者的术后6周期辅助化疗。方法OFL方案治疗过程中,因出现严重的化疗毒副反应,预计无法完成6周期术后辅助化疗,改用XELOX(奥沙利铂+卡培他滨)方案化疗。结果12例顺利完成剩余周期化疗,未产生严重毒副反应。结论对无法耐受OFL方案化疗的胃癌或结肠癌患者,XELOX方案是一种可行的选择。Objective To finish the six cycles of chemotherapy for the 13 patients who couldn＇ t tolerate toxicity of OFL（ oxaliplatin plus LV/ 5-Fu regimen） in the treatment of advanced gastric or colon carcinoma. Methods The 13 patients with advanced gastric or colon carcinoma were treated with XELOX（ xeloda plus oxaliplatin regimen） chemotherapy after the second or third cycles instead of OFL regimen chemotherapy which caused severe toxic reation such as diarrhea, haematological adverse reaction. Results The 12 patients finished total 6 cycles and toxic reation was mild, and the last patient finished total 6 cycles with xeloda only. Conclusion XELOX was active and well tolerated as a first-line therapy to replace OFL for the treatment of advanced gastric or colon carcinoma patients.

关 键 词：XELOX OFL 胃癌 结肠癌 毒副反应 

分 类 号：R730.53[医药卫生—肿瘤] R735.2[医药卫生—临床医学]