β-环糊精衍生物对美洛昔康的包合作用  

Inclusion Interaction of Meloxicam with β-Cyclodextrin Derivatives

作　　者：王茹林[1] 孙体健[1] 裴晓丽[2] 刁海鹏[1] 陈明兰[1] 

机构地区：[1]山西医科大学化学教研室,太原030001 [2]山西中医学院实验管理中心,太原

出　　处：《应用化学》2008年第10期1221-1224,共4页Chinese Journal of Applied Chemistry

基　　金：山西省科技厅自然科学基金(20051029)资助项目

摘　　要：采用荧光光谱法在pH值2.5、6.8和10.0的磷酸盐缓冲溶液中,研究了美洛昔康与β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)和磺丁醚-β-环糊精(SBE-β-CD)的包合特性。美洛昔康的最大发射波长依次紫移了7、9和14 nm,荧光强度变化(ΔF)的倒数与环糊精浓度(cCD)的倒数呈线性关系。结果表明,其与3种环糊精均形成了1∶1的包合物。以包合常数作为包合作用的量度,则在酸性和中性条件下包合能力呈SBE-β-CD>HP-β-CD>β-CD。包合过程除了疏水作用力外,还存在额外的静电作用力。In phosphate buffer midia the inclusion behavior beween meloxicam and β-cyclodextrin（β-CD）,hydroxyproyl-β-cyclodextrin（HP-β-CD） and sulfobutyl ether-β-cyclodextrin（SBE-β-CD） was studied by fluorescence spectroscopy.It showed that 1∶1 inclusion complexes were formed beween meloxicam and the three kinds of CDs,because the emission maximum shifted by 7,9,and 14 nm,respectively and the reciprocal of change in fluorescence intensity（ΔF） was directly proportional to the reciprocal of the CD concentration（CCD）.The binding ability was SBE-β-CD〉HP-β-CD〉β-CD in acidic and neutral media based on the formation constants.There were not only hydrophobic but also electrostatic forces involved.

关 键 词：美洛昔康 Β-环糊精衍生物 包合作用 荧光光谱法 

分 类 号：O629.1[理学—有机化学] O626[理学—化学]