薯蓣皂苷类化合物体外抗肿瘤作用的研究  

Study on antitumor effects of dioscin compounds in vitro

作　　者：马朋[1] 曹同涛[1] 刘栋[1] 姜涛[1] 王慧林 

机构地区：[1]滨州医学院基础学院,滨州市256603 [2]烟台市牟平区人民医院

出　　处：《滨州医学院学报》2008年第5期326-328,共3页Journal of Binzhou Medical University

基　　金：滨州医学院科技计划项目(BY2005KJ09);国家自然科学基金(30330690)

摘　　要：目的探讨薯蓣皂苷类化合物的体外抗肿瘤作用。方法用酸性磷酸酶法分别检测五种薯蓣皂苷对人源性肝癌BEL-7404细胞株体外生长的抑制作用。结果五种薯蓣皂苷对所试肿瘤细胞株的体外生长皆有一定的抑制作用,尤其是薯蓣皂苷5对肝癌细胞的生长抑制作用较强,抑制率达到90%以上。结论体外实验表明五种薯蓣皂苷皆具有一定的抗肿瘤细胞生长作用,其中具有末端β-半乳糖基的薯蓣皂苷5抗肿瘤细胞毒活性最高。Objective To examine antitumor activity of dioscins on tumor cell line in vitro. Methods Acid phosphatase assay （APA） was adopted to detect in vitro the effects of these drugs on the growth of tumor cell line. Results Five kinds of dioscins had inhibitory effects on tested tumor cell line. Especially,the growth inhibitory ratio of dioscin 5 on BEL-7404 cell line reached above 90%, which was highest among them. Conclusion Our results revealed that the five kinds of dioscin had potent inhibitory effects on BEL- T404 cell line with different degree. Dioscin 5, which has β-galactosyl at the terminal, showed the strongest cytotoxicity on the growth of tumor cell line among them.

关 键 词：薯蓣皂苷 酸性磷酸酶法 抗肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]