健脾化瘀中药逆转肝癌免疫逃逸  

Chinese Drugs of Spleen-invigorating and Blood Stasis-removing Revise Immune Escape of Liver Cancer Cells

作　　者：王昌俊[1] 

机构地区：[1]广东省人民医院中西医结合科,广东广州510080

出　　处：《中华中医药学刊》2008年第10期2131-2133,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：肿瘤的归宿取决于肿瘤细胞与宿主的相互作用。肝癌细胞逃避免疫系统监视是肝细胞癌术后复发和转移的重要原因。肝癌患者免疫功能低下,主要表现为T细胞活化障碍,癌细胞逃避机体免疫监视而产生免疫逃逸。健脾药物可提高肝癌患者机体免疫功能,化瘀药物可改善肝癌局部微环境紊乱状态,抑制肿瘤微血管生成,从而改善免疫抑制状态。健脾化瘀治疗可治理肝癌患者微环境,纠正细胞因子和转录因子的异常表达,改变T淋巴细胞亚群的失衡状态,提高T淋巴细胞活性,增强T细胞对肿瘤细胞的识别功能,逆转肝癌免疫逃逸。The end result of cancer depends on interaction of cancer cells and the host immunity. Cancer cells evade immune surveillance is the important reasons of recurrence and metastasis of hepatocellular carcinoma. Immunity of liver cancer patients is compromised, mainly for T - cells inactivation and cancer cells evading of immune surveillance. Chinese drugs of spleen -invigorating （Jianpi） Chinese drugs can enhance host immunity, blood stasis -removing （Huayu） improve the local micro - environment state of liver cancer and inhibit tumor angiogenesis to revise the status of immunosuppressive. Therefore, we propose treatment of Jianpi and Huayu can restore micro -environment and reverse immune escape of liver cancer cells by regulating abnormal expression of cytokines and transcription factors, re - balancing the T - lymphocyte subsets, improving the activity of T - lymphocyte and its recognition of tumor cells.

关 键 词：肝癌 健脾化瘀 免疫逃逸 

分 类 号：R735.7[医药卫生—肿瘤]