消臌软坚丸对肝硬化大鼠碱性成纤维细胞生长因子的影响  

Experimental Effect of Xiaogu Ruanjian Pill on Cirrhosis Rat's Blood and Liver Basic Fibroblast Growth Factor

作　　者：戚忠玺 耿兰书 耿束华 王少贤[2] 魏萱[2] 

机构地区：[1]河北中医肝病医院,河北正定050800 [2]河北医科大学中医学院,河北石家庄050091

出　　处：《中华中医药学刊》2008年第10期2212-2213,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省中医药管理局科学研究计划课题(2007150)

摘　　要：目的:观察消臌软坚丸对肝硬化大鼠碱性成纤维细胞生长因子(bFGF)的影响。方法:采用复合因素造模法复制肝硬化大鼠模型,以复方鳖甲软肝片为对照,观察消臌软坚丸对大鼠肝脏病理形态学和TGF-α的影响。结果:与正常组比较,模型组大鼠肝间质广泛纤维组织增生,将正常肝小叶分割成大小不等的肝细胞团(即假小叶形成),肝组织bFGF含量明显升高(P<0.01)。与模型组比较,高、低剂量组和对照组肝小叶结构亦受损,少量纤维组织增生,但未见形成间隔。肝组织bFGF含量明显下降(P<0.05或P<0.01)。结论:消臌软坚丸能显著改善肝硬化大鼠的肝脏病理组织学损害,同时可降低肝组织bFGF水平,具有显著的抗肝脏纤维化,阻断肝硬化进程的作用,对腹水的产生与消退也产生积极的影响。Objective： To observe the effect of Xiaogu Ruanjian pill on liver Cirrhosis rats blood and liver basic fibroblast growth faetor（bFGF）. Methods： Reproduced the rats models of cirrhosis by adopting complex factors, compared with Fufang Biejia Ruanganpill , the effect of Xiaogu Ruanjian Pill on hepatic pathology and bFGF were observed. Results： Compared with normal group, extensive fibrous tissue hyperplasia can be seen in hepatic mesenehyme of the model group, the liver pseudolobule formed, the contents of bFGF in liver were increased （ P 〈 0. 01 ）. Compared with model group, there were a few fibrous tissue hyperplasia in high - dosage group, low - dosage group and control group, no fibrofie septa formed. The contents of bFGF in liver were decreased（ P 〈 0. O1 or P 〈 0. 05）. Conclusion： Xiaogu Ruanfian pill could obviously improve the cirrhosis rat pathology, decrease the contents of bFGF in liver, decrease or restrain the happening or development of ascites.

关 键 词：消臌软坚丸 肝硬化 病理形态学 碱性成纤维细胞生长因子 

分 类 号：R-33[医药卫生]