胃癌组织中PTEN、caspase-3表达与临床病理特征的关系  

Expressions of PTEN and caspase-3 in gastric cancer and their correlations with clinical pathological features of the tumor

作　　者：程骏[1] 余作黔[1] 韩少良[1] 黄颖鹏[1] 吴秀玲[2] 万丽[2] 朱冠保[1] 

机构地区：[1]温州医学院第一附属医院胃肠外科,浙江温州325000 [2]温州医学院第一附属医院病理科,浙江温州325000

出　　处：《温州医学院学报》2008年第5期435-437,共3页Journal of Wenzhou Medical College

基　　金：温州市科技局科研基金资助项目(Y2004A135)

摘　　要：目的:探讨PTEN、caspase-3在胃癌组织中的表达及其与临床病理特征之间的相关性。方法:用免疫组织化学Envison法检测73例胃癌及20例正常胃黏膜组织中PTEN、caspase-3的表达情况。结果:①PTEN和caspase-3在胃癌组织中表达下调,阳性表达率分别为39.7%(29/73)和21.9%(16/73)。②PTEN表达随肿瘤分化程度的降低、浸润深度加深、淋巴结转移增多、临床分期提高而降低,青年组比中老年组表达低。③caspase-3阳性表达随肿瘤分化程度的降低、临床分期提高而降低。④胃癌组织中PTEN与caspase-3的表达呈正相关(r=0.653,P<0.01)。结论:PTEN、caspase-3的表达下调与胃癌的发生、发展有关,二者可作为判定胃癌生物学行为和预后的临床参考指标。Objectire： To investigate the protein expressions of PTEN and caspase-3 in gastric cancer and the relationship between their expressions and cliniealpathological features.Methods： Protein expressions of Pit, and caspase-3 in paraffin embedded tissues from 73 cases of gastric cancer and 20normal gastric mueosa tissues were analyzed by immunohistochemical Envision method. Results： （1）Expressions of PTEN and caspase-3 in gastric cancer were lower than that in the normal gastric mucosa tissues; their expression rates were 39.7% （29/73） and 21.9% （16/73） respectively; （2）The expression of PTEN in welldifferentiated adenocarcinoma was higher than that in poorly-differentiated adenocarcinoma. Also, the lost or decreased expression of PTEN significantly correlated with infiltrative depth, lymph node metastasis, clinicalpathological stage and young cases; （3）Moreover, the lower expression of caspase-3 correlated with poorly-differentiated adenocarcinoma and clinicalpathological stage; （4）Signifieant relationships were found between PTEN and caspase-3 （r=0.653, F〈 0.01）. Conclusions： This expreiment suggests that PTEN, and caspase-3 may play certain roles in the oncogenesis and progression of gastric cancer. Their expressions may be favorable markers and useful prognostic indicators in the patients with gastric cancer.

关 键 词：胃癌 PTEN CASPASE-3 免疫组织化学 

分 类 号：R735[医药卫生—肿瘤]