Esophageal epithelial surface in patients with gastroesophageal reflux disease:An electron microscopic study  

作　　者：Takane Azumi Kyoichi Adachi Kenji Furuta Shuji Nakata Shunji Ohara Kenji Koshino Masaharu Miki Terumi Morita Takashi Tanimura Nobuo Ashizawa Yoshikazu Kinoshita 

机构地区：[1]Second Department of Internal Medicine, Shimane University School of Medicine,Shimane 693-8501, Japan

出　　处：《World Journal of Gastroenterology》2008年第37期5712-5716,共5页世界胃肠病学杂志（英文版）

基　　金：The Grants-in-Aid from Science Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, No. 19590724

摘　　要：A/M： To investigate the intercellular spaces between the most superficially located esophageal epithelial cells in patients with gastroesophageal reflux disease （GERD）. METHODS： Eighteen patients with erosive esophagitis, 10 patients with non-erosive reflux disease （NERD）, and 18 normal asymptomatic volunteers were enrolled. Biopsy specimens were obtained from the lower esophageal mucosa without ulcer or erosion. Scanning electron microscopy was employed to investigate the tightness of the superficial cellular attachment. RESULTS： The intercellular space between the most superficially located epithelial cells in patients with erosive esophagitis or NERD was not different from that in asymptomatic healthy individuals. CONCLUSION： Widened luminal intercellular spaces of esophageal superficial epithelium are not responsible for the induction of reflux symptoms in patients with GERD.AIM: To investigate the intercellular spaces between the most superficially located esophageal epithelial cells in patients with gastroesophageal reflux disease (GERD). METHODS: Eighteen patients with erosive esophagitis, 10 patients with non-erosive reflux disease (NERD), and 18 normal asymptomatic volunteers were enrolled. Biopsy specimens were obtained from the lower esophageal mucosa without ulcer or erosion. Scanning electron microscopy was employed to investigate the tightness of the superficial cellular attachment. RESULTS: The intercellular space between the most superficially located epithelial cells in patients with erosive esophagitis or NERD was not different from that in asymptomatic healthy individuals. CONCLUSION: Widened luminal intercellular spaces of esophageal superficial epithelium are not responsible for the induction of reflux symptoms in patients with GERD.

关 键 词：Reflux esophagitis Non-erosive gastroesophageal reflux diseases Electron microscopy QUESTIONNAIRE 

分 类 号：R571[医药卫生—消化系统]