炎症性肠病肠黏膜组织内淋巴细胞激活和效应应答  

Intestinal mucosal lymphocyte activation and effective response in inflammatory bowel disease

作　　者：任宏宇[1] 邹开芳[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院消化内科,湖北省武汉市430022

出　　处：《世界华人消化杂志》2008年第28期3178-3180,共3页World Chinese Journal of Digestology

摘　　要：肠黏膜淋巴细胞的异常激活,导致对正常肠黏膜组织的损伤免疫应答,是炎症性肠病(IBD)发生的关键病理特征.在IBD肠道黏膜免疫反应中,固有层成为黏膜免疫应答的主要效应场所,上皮内淋巴细胞和固有层淋巴细胞发挥着重要作用,分泌淋巴细胞因子和产生免疫球蛋白.针对不同抗原,B、T淋巴细胞的激活和效应应答各异,B淋巴细胞产生多种损伤性抗体,T淋巴细胞有Th1和Th17淋巴细胞的过度反应、调节性T淋巴细胞的缺陷等,本文在此进行了相关的综合评价.Gut mucosal lymphocytes are actived abnormally in inflammatory bowel disease （IBD）, characterized by harmful immune responses in normal gut mucosa. In gut mucosal immune response, lamina propria is a major effective site, and intraepithelial lymphocytes and lamina propria lymphocytes play important roles, secreting antibodies and lymphocyte factors. B and T lymphocyte activation and effective response are different according to various antigens. B lymphocytes produce antibodies harmful to mucosa, while T lymphocytes （Th1 and Th17） appear to be over-reacted. Mover, regulatory T lymphocyte defection is also a problem. In this paper, we give comprehensive evaluation on the above points.

关 键 词：炎症性肠病 淋巴细胞 效应应答 

分 类 号：R574[医药卫生—消化系统]