胰腺抗生素浓度在防治重症急性胰腺炎继发感染中的作用  

Value of pancreatic antibiotic concentration in treatment of secondary infection of serve acute pancreatitis

作　　者：邓力珲[1] 夏庆[1] 

机构地区：[1]四川大学华西医院中西医结合科,四川省成都市610041

出　　处：《世界华人消化杂志》2008年第27期3077-3082,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30500684;四川大学华西医院住院医师临床科研奖励基金资助课题~~

摘　　要：胰腺继发感染是重症急性胰腺炎(severe acute pancreatitis,SAP)最严重的并发症.防治胰腺感染已成为进一步降低SAP病死率的关键.对血-胰屏障结构和功能的认识和不同抗生素在胰腺局部浓度和渗透力的研究,促进防治SAP胰腺感染时抗生素的合理选择.研究能够提高抗生素在胰腺组织浓度、增强抗生素疗效的治疗方法与药物,有望进一步阐明某些药物治疗SAP的作用机制,有助于SAP继发感染的预防与治疗.Secondary pancreatic infection represents the most serious complication with fatal outcome in severe acute pancreatitis （SAP）. Preventing and curing secondary infection of pancreas is the key obstacle to minimize the mortality of these patients. The studies on blood-pancreatic juice barrier as well as penetration and pancreatic tissue concentration of antibiotics have improved the antibiotic prophylaxis or treatment of pancreatic infection. In the future, potential therapeutics that can enhance the antibiotic concentration and efficacy may help to prevent and treat the secondary infection of SAP.

关 键 词：抗生素 急性胰腺炎 血胰屏障 方法学 

分 类 号：R576[医药卫生—消化系统]