肾衰养真胶囊对5/6肾切除慢性肾衰营养不良大鼠营养状态的影响  

Effect of Capsule of Shenshuai Yangzhen on Malnutrition Rats with Chronic Renal Failure by 5/6 Nephrectomy

作　　者：魏连波[1] 邓聪[1] 陈杰彬[1] 李玉明[1] 黄丽雯[1] 龚春水[1] 

机构地区：[1]南方医科大学珠江医院中西医结合肾病中心/国家中医药管理局肾病重点学科,广东广州510282

出　　处：《中药材》2008年第9期1391-1395,共5页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(NO.30672768);广东省自然科学基金(NO.06024428);广州市科技基金(NO.2006Z3-E5051-1);南方医科大学开发基金(NO.200601);珠江医院院长基金(NO.200302)

摘　　要：目的:观察肾衰养真胶囊对5/6肾切除慢性肾衰竭(CRF)营养不良大鼠营养状态的影响。方法:5/6肾切除同时予4%酪蛋白饮食制作CRF营养不良大鼠模型,观察其营养不良发生时间,将符合条件的大鼠随机分为正常组、模型组、肾衰养真胶囊组和开同组。治疗4周后检测体重、白蛋白、血红蛋白、甘油三脂、总胆固醇、胰岛素样生长因子-1等指标的变化,进行光镜(HE、PAS染色)观察肾组织病理学改变。结果:大鼠在5/6肾切后10周末出现营养不良,与模型组比较,经治疗4周后肾衰养真胶囊组大鼠体重及摄食量显著增加白蛋白、血红蛋白、胰岛素样生长因子-1、甘油三脂、总胆固醇水平显著升高,肾组织病理形态明显改善,肾功能有明显的改善。结论:肾衰养真胶囊能改善5/6肾切慢性肾衰竭营养不良模型大鼠的营养状态。Objective：To investigate the effects of capsule of Shenshuai Yangzhen, a preparation of traditional Chinese medicine, on malnutrition rats with chronic renal failure（CRF）. Methods：SD rats received 5/6 nephrectomy for preparation of CRF models, and fed 4% casein at the same time. Observed when malnutrition began. Those consistents with malnutrition of CRF condition were randomized into model control group, Ketosteril group, Shenshuai Yangzhen group, and normal control group. After 4-weeks treatment as indicated, The blood parameters, like blood serum albumin（ ALB）, type-1 insulin like growth factor（ IGF-1 ）, total cholesterol（TC） , triglyeride （TG）, urea nitrogen（ BUN）, serum creatinine （Scr）, haemoglobin （Hb）, 24 hour urineprotein （24hUpr） and weight were determined. Nephrotic tissue was observed by microscope（ included HE and PAS）. Results： Malnutrition situation in CRF rats began at the end of 10-weeks. After 4-weeks treatment, weight in Shenshuai Yangzhen group were higher significantly（ P 〈 0. 05 ）. Compared with model control group, blood serum BUN（ P 〈0. 05 ）, SCr （P 〈 0. 05） and 2dhUpr（ P 〈 0. 001 ） in Shenshuai Yangzhen group were significantly lower with substantially elevated blood serum ALB, Hb, IGF-1 （ P 〈 0. 01 ; P 〈 0. 001 ; P 〈 0. 001, respectively）. Pathology of Shenshuai Yangzhen group was a meliorated significantly after treated. Conlusion ： Capsule of Shenshuai Yangzhen has a possible therapic effect on improving malnutrition in rats with renal insufficiency.

关 键 词：肾衰养真胶囊 慢性肾衰竭 营养不良 

分 类 号：R285.5[医药卫生—中药学]