McAbGB_2识别的乳腺癌血清抗原水平观察  

Detection of the Level of Serum Antigen Recognized by McAbGB2 in Breast Cancer

作　　者：蔡桂英[1] 魏玲 樊安银[1] 

机构地区：[1]四川省肿瘤医院乳腺科

出　　处：《华西医科大学学报》1997年第4期369-371,共3页Journal of West China University of Medical Sciences

基　　金：国家教委博士点学科专项基金

摘　　要：为探明乳腺癌患者由ＭｃＡｂＧＢ２识别的乳腺癌血清抗原（以下简称血清ＭｃＡｂＧＢ２抗原）水平，应用ＥＬＩＳＡ方法，用抗人乳腺癌血清抗原ＭｃＡｂＧＢ２观察了５０例正常人和６０例乳腺癌患者血清ＭｃＡｂＧＢ２抗原水平。结果：１７例乳腺癌患者术前的血清ＭｃＡｂＧＢ２抗原水平与正常人之间有显著性差异（Ｐ＜０．００１），其阳性符合率达８８．２％（１５／１７）。其中８例乳腺癌患者的血清ＭｃＡｂＧＢ２抗原水平由术前的５７．５±５１．３ｕ／ｍｌ降至术后的２０．６±４．９８ｕ／ｍｌ。４３例在化疗中的乳腺癌术后患者的血清ＭｃＡｂＧＢ２抗原多处于正常水平。由此提示血清ＭｃＡｂＧＢ２抗原可作为乳腺癌标志物，用于乳腺癌的血清学诊断。This study sought to verify the levels of serum antigen recognized by McAbGB2 (abbr. serum McAbGB2 antigen) in patients with breast cancer. We adopted the ELISA method and used McAbGB2 to detect the level of serum McAbGB2 antigen in 50 normal persons and 60 patients with breast cancer. The results showed that the level of serum McAbGB2 antigen of 17 preoperative patients with breast cancer was significantly different from that of the normal persons (P<0.001); the rate of agreement on positivity for the 17 preoperative patients with breast cancer was 88.2% (15/17); the levels of serum McAbGB2 antigen in 8 patients among the 17 preoperative patients with breast cancer decreased from 57.5±51.3u/ml (preoperation) to 20.6±4.98u/ml (postoperation; the levels of serum McAbGB2 antigen in the other 43 operated patients with breast cancer almost remained normal during postoperative chemotherapy. These suggest that serum McAbGB2 antigen is a marker for breast cancer and can be used for serological diagnosis, treatment and prognosis inspection.

关 键 词：乳腺癌 ELISA 单克隆抗体 血清学 

分 类 号：R737.9[医药卫生—肿瘤]