多肿瘤标志物蛋白芯片检测在肺癌诊断中的价值  

Evaluation of multiple tumor marker protein biochip detective system in diagnosis of lung cancer

作　　者：段玉忠[1] 蒋仁容[2] 曹正怀[1] 

机构地区：[1]第三军医大学新桥医院肿瘤科,重庆市400037 [2]第三军医大学核医学科,重庆市400037

出　　处：《实用医学杂志》2008年第19期3318-3320,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:30400407)

摘　　要：目的:探讨多种肿瘤标志物蛋白芯片检测系统在肺癌诊断中临床应用价值。方法:应用化学发光法多种肿瘤标志物蛋白芯片检测系统,测定并分析254例病理或细胞学首次确诊的肺癌患者,以及276例健康体检者血清中12种肿瘤标志物(CA19-9、NSE、CEA、CA242、CA125、CA153、AFP、ferritin、f-PSA、PSA、β-HCG及HGH)的表达水平。结果:肺癌组的C-12芯片检测阳性率显著高于健康体检组(68.90%vs17.03%,χ2=152.95,P<0.01),敏感性和特异性分别为68.9%和82.9%;肺癌组中ferritin、CA125、CEA及CA19-9的阳性率分别为41.04%、35.86%、33.47%和13.15%。结论:多肿瘤标志物蛋白芯片检测系统在肺部恶性病变的诊断中有较高的临床应用价值。Objective To explore the clinical application value of multiple tumor marker protein biochip detective system in diagnosis of lung cancer. Methods Serum levels of twelve tumor markers such as CA 19-9, NSE, CEA, CA242, CA125, CA153, AFP, ferritin, f-PSA, PSA, β-HCG and HGH in 276 healthy volunteers and 254 pathologically or cytological diagnosed lung cancer patients were measured and analysed with a C-12 multiple tumor marker protein biochip detective system respectively. Results The positive rate of the C-12 multiple tumor marker proteins in lung cancer group was significantly higher than that of healthy volunteers group （68.90% vs 17.03%, x^2 = 152.95, P 〈 0.01）, the sensitivity and specificity was 68.9% and 82.9% respectively. The positive rates of ferritin, CA125, CEA and CA19-9 were 41.04%, 35.86%, 33.47% and 13.15% respectively in lung cancer group. Conclusion C-12 multiple tumor marker protein biochip detective system has relatively high practical application value in the diagnosis of lung cancer.

关 键 词：肺肿瘤 肿瘤标志物 蛋白芯片 

分 类 号：R734.2[医药卫生—肿瘤]