基于N-(9-蒽甲基)-L-组氨酸的NOR荧光逻辑门  

A NOR Fluorescent Logic Gate Based on N-(9-Anthracylmethyl)- L-histidine

作　　者：宗国强[1,2] 吕功煊[1] 

机构地区：[1]中国科学院兰州化学物理研究所,羰基合成与选择氧化国家重点实验室,兰州730000 [2]中国科学院研究生院,北京100049

出　　处：《物理化学学报》2008年第10期1902-1906,共5页Acta Physico-Chimica Sinica

基　　金：国家自然科学基金(90210027)资助项目

摘　　要：合成了一个新的组氨酸衍生物,N-(9-蒽甲基)-L-组氨酸(1),并对其进行了元素分析、电喷雾电离质谱(ESI-MS)、核磁共振氢谱(1H-NMR)和碳谱(13C-NMR)等波谱表征.考查了pH值及15种不同金属离子对其荧光强度的影响.实验结果表明,中性水溶液条件下,Zn2+和Cd2+能使体系荧光增强,而Pb2+、Co2+、Hg2+、Ni2+和Cu2+等则使体系荧光有不同程度的猝灭.其中,Cu2+和Ni2+猝灭能力最强,它们与化合物1均形成了物质的量比为1∶2的配合物,络合常数分别为2.88×106和1.12×106L2·mol-2.Cu2+和Ni2+对化合物1的荧光猝灭为静态猝灭过程.在此基础上,以Cu2+和Ni2+作为两个输入信号,以蒽的特征荧光发射作为输出信号,构建了一个NOR荧光分子逻辑门.A new compound, N-（9-anthracylmethyl）-L-histidine （1）, was synthesized and characterized by elemental analysis, electrospray ionization mass spectrometry （ESI-MS）, ^1H-NMR, and ^13C-NMR, etc. The effects of pH values and metal ions on the fluorescent intensity of compound 1 were studied. In neutral aqueous solutions, the fluorescence intensity of compound 1 increased upon addition of Zn^2＋ or Cd^2＋, while other metal ions （Pb^2＋, Co^2＋, Hg^2＋, Ni^2＋, and Cu^2＋） quenched the fluorescence. Among these metal ions, Cu^2＋ and Ni^2＋ had the strongest quenching capacity. They both formed a stable complex with compound 1 （1：2 molar ratio）, and the complex constants were 2.88×10^6 and 1.12×10^6 L2·mol^-2, respectively. The experimental results showed that static quenching was involved in adding Cu^2＋ or Ni^2＋ in aqueous solution of compound 1. On the basis of these studies, a NOR fluorescent molecular logic gate was fabdcated with Cu^2＋ and Ni^2＋ as two inputs and with emission of anthracene as the output.

关 键 词：荧光逻辑门 L-组氨酸 蒽 CU2+ NI2+ 

分 类 号：TN791[电子电信—电路与系统]