Synchronous granulocytic sarcoma of the breast and spine： a case report and review of the literature  

作　　者：CUI Yan ZHOU Jin-lian WU Ji-hua ZHANG Jian-zhong 

机构地区：[1]Department of General Surgery 306 Hospital of People's Liberation Army, Beijing 100101, China [2]Department of Pathology 306 Hospital of People's Liberation Army, Beijing 100101, China

出　　处：《Chinese Medical Journal》2008年第18期1854-1856,共3页中华医学杂志（英文版）

摘　　要：Granulocytic sarcoma or chloroma is a rare tumour derived from myeloid cell precursors. It is generally seen before or after or together with the onset of myelocytic leukaemia. Immunohistochemical staining of myeloperoxidase is necessary for a definite diagnosis of granulocytic sarcoma. Recognition of this entity ensures an early aggressive chemotherapy that causes regression of the tumour.1-3 We present an unusual case of a 40-year-old woman who presented with back pain, numbness in the legs, and fatigue for 2 weeks. She was diagnosed as having synchronous granulocytic sarcomas of the breast and spine, confirmed surgically and histopathologically. After a subsequent systemic chemotherapy the patient was completely asymptomatic during a 20-month follow-up. We also reviewed the literature about the clinical manifestations, diagnosis, treatment, and prognosis of this condition.Granulocytic sarcoma or chloroma is a rare tumour derived from myeloid cell precursors. It is generally seen before or after or together with the onset of myelocytic leukaemia. Immunohistochemical staining of myeloperoxidase is necessary for a definite diagnosis of granulocytic sarcoma. Recognition of this entity ensures an early aggressive chemotherapy that causes regression of the tumour.1-3 We present an unusual case of a 40-year-old woman who presented with back pain, numbness in the legs, and fatigue for 2 weeks. She was diagnosed as having synchronous granulocytic sarcomas of the breast and spine, confirmed surgically and histopathologically. After a subsequent systemic chemotherapy the patient was completely asymptomatic during a 20-month follow-up. We also reviewed the literature about the clinical manifestations, diagnosis, treatment, and prognosis of this condition.

关 键 词：granulocytic sarcoma CHLOROMA breast tumor thoracic epidural tumor 

分 类 号：R733.7[医药卫生—肿瘤] R737.9[医药卫生—临床医学]