低氧诱导因子-1α基因多态性与肿瘤易感性  

Polymorphisms of Hypoxia Inducible Factor-1α Gene and Susceptibility to Cancers

作　　者：张小爱[1] 周钢桥[1] 贺福初[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京蛋白质组研究中心,蛋白质组学国家重点实验室,北京102206

出　　处：《生物技术通讯》2008年第5期721-723,共3页Letters in Biotechnology

基　　金：国家高技术研究发展计划(2006AA02A412);国家自然科学基金委创新研究群体科学基金(30621063);国家重点基础研究发展计划(2006CB910803);北京市科技新星人才基金(2006A54)

摘　　要：低氧诱导因子-1(HIF-1)是参与调节机体氧平衡的重要转录因子,HIF-1α是其主要的氧调节亚基和功能亚基,体内HIF-1α的水平直接影响着肿瘤的易感性。简要介绍了HIF-1α的生物学功能,并对近年来HIF-1α基因多态性与肿瘤易感性的研究进展进行了回顾。Hypoxia inducible factor-1 （HIF-1） plays an important role in oxygen homeostasis of the organism. HIF-1 composed of two subunits, HIF-1α and HIF-1β, and among which the HIF-1α is the major regulator of the HIF-1. The levels of HIF-1α produced in vivo influence susceptibility to and severity of cancers, in this review, the biological role of HIF-1α was discussed, and the recent advances of the HIF-1α polymorphisms as well as its associations with the susceptibility to cancers were summarized.

关 键 词：低氧诱导分子-1α 基因多态性 遗传易感性 肿瘤 

分 类 号：Q75[生物学—分子生物学] R730.2[医药卫生—肿瘤]