转化生长因子-β_1及VEGF在肝纤维化中的表达  

Expression of TGF-β_1 and VEGF in forming course of hepatic fibrosis

作　　者：郭艳萍[1] 杨广英[1] 王建君[1] 姜黄[1] 李军[1] 

机构地区：[1]郑州人民医院病理科,郑州市450003

出　　处：《中华实用诊断与治疗杂志》2008年第10期724-725,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：郑州市2007年度科技发展计划(15-5)

摘　　要：目的:观察肝组织TGF-β1及VEGF在肝纤维化形成过程中的作用及意义。方法:采用免疫组织化学方法检测36例慢性病毒性肝炎、肝纤维化、肝硬化TGF-β1及VEGF的表达。结果:随着慢性病毒性肝炎、肝纤维化及肝硬化的形成,TGF-β1及VEGF表达逐渐增强(P<0.01)。结论:肝组织中TGF-β1及VEGF的表达与肝纤维化及肝硬化的形成密切相关,可作为诊断和治疗早期肝纤维化的重要指征。Objective To observe changes of TGF-β1 and VEGF in the forming course of hepatic fibrosis and their effective and significance. Methods The levels of TGF-β1 and VEGF were measured by immunohistochemistry in 36 cases of viral hepatitis, liver fibrosis and liver cirrhosis. Results During hepatic fibrosis induced, expressions of TGF-β1 and VEGF increased gradually. Conclusion TGF-β1 and VEGF are closely related to hepatic fibrosis and liver cirrhosis, which are important indicators for the diagnosis and therapy of primary of hepatic fibrosis.

关 键 词：慢性病毒性肝炎 肝纤维化 肝硬化 转移生长因子-Β1 VEGF 免疫组织化学 

分 类 号：R575.2[医药卫生—消化系统]