Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium  

作　　者：Chieh-fu CHEN Wen-fei CHIOU Jun-tian ZHANG 

机构地区：[1]Institute of Pharmacology, National Yang-Ming University, TaipeL China [2]National Research Institute of Chinese Medicine, Taipei, China [3]Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China [4]Peking Union Medical College, Beijing 100050. China

出　　处：《Acta Pharmacologica Sinica》2008年第9期1103-1108,共6页中国药理学报（英文版）

摘　　要：Medical application of Panax ginseng was first found in ＂Shen-Nong Herbal Classic＂ around 200 AD Panax quinquefolium was first introduced in ＂Essential of Materia Medica＂ in 1694 in China. The most important bioactive components contained in P ginseng and P quinquefolium are ginseng saponins （GS）. The contents of ginsenoside Rb 1, Re, and Rd in P quinquefolium are higher than they are in P ginseng. In P ginseng, the contents of Rg 1,Rb2, and Rc are higher than they are in P quinquefolium. P ginseng had a higher ratio of Rgl： Rbl, and which was lower in P quinquefolium. After steaming for several hours, the total GS will decrease. However, some ginsenosides （Rg2, 20R-Rg2, Rg3, Rhl and Rh2） increase, while others （Rbl, Rb2, Rb3, Rc, Rd, Re, and Rg1） decrease. However, variation, especially in P quinquefolium, is high. P ginseng and P quinquefolium are general tonics and adaptogens. Rgl and Rbl enhance central nervous system （CNS） activities, but the effect of the latter is weaker. Thus, for the higher contents of Rgl, P ginseng is a stimulant, whereas the Rbl contents of P quinquefolium are mainly calming to the CNS. Re, Rg1, panaxan A and B from P ginseng are good for diabetes. Re and Rgl enhance angiogenesis, whereas Rb1, Rg3 and Rh2 inhibit it. Rh2, an antitumor agent, can be obtained from Rbl by steaming. The content of Re in P quinquefolium are higher than in P ginseng by 3-4 times. The vasorelax, antioxidant, antihyperlipidemic, and angiogenic effects of Re are reported. Thus, for the CNS ＂hot,＂ wound healing and hypoglycemic effects, P ginseng is better than P quinquefolium. For anticancer effects, P quinquefolium is better.Medical application of Panax ginseng was first found in ＂Shen-Nong Herbal Classic＂ around 200 AD Panax quinquefolium was first introduced in ＂Essential of Materia Medica＂ in 1694 in China. The most important bioactive components contained in P ginseng and P quinquefolium are ginseng saponins （GS）. The contents of ginsenoside Rb 1, Re, and Rd in P quinquefolium are higher than they are in P ginseng. In P ginseng, the contents of Rg 1,Rb2, and Rc are higher than they are in P quinquefolium. P ginseng had a higher ratio of Rgl： Rbl, and which was lower in P quinquefolium. After steaming for several hours, the total GS will decrease. However, some ginsenosides （Rg2, 20R-Rg2, Rg3, Rhl and Rh2） increase, while others （Rbl, Rb2, Rb3, Rc, Rd, Re, and Rg1） decrease. However, variation, especially in P quinquefolium, is high. P ginseng and P quinquefolium are general tonics and adaptogens. Rgl and Rbl enhance central nervous system （CNS） activities, but the effect of the latter is weaker. Thus, for the higher contents of Rgl, P ginseng is a stimulant, whereas the Rbl contents of P quinquefolium are mainly calming to the CNS. Re, Rg1, panaxan A and B from P ginseng are good for diabetes. Re and Rgl enhance angiogenesis, whereas Rb1, Rg3 and Rh2 inhibit it. Rh2, an antitumor agent, can be obtained from Rbl by steaming. The content of Re in P quinquefolium are higher than in P ginseng by 3-4 times. The vasorelax, antioxidant, antihyperlipidemic, and angiogenic effects of Re are reported. Thus, for the CNS ＂hot,＂ wound healing and hypoglycemic effects, P ginseng is better than P quinquefolium. For anticancer effects, P quinquefolium is better.

关 键 词：Panax ginseng   Panax quinquefolium steaming ginseng GINSENOSIDES ginseng saponins pharmacological effects chemical components 

分 类 号：R96[医药卫生—药理学]