GINSENOSIDES

作品数：89被引量：407H指数：11
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相关领域：医药卫生更多>>
相关作者：难波恒雄刘进怀蔡少青王璇陈颖更多>>
相关机构：中国科学院沈阳药科大学富山医科药科大学北京大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金国家教育部博士点基金更多>>
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Identification and Prediction of Key Technologies in Ginsenosides Based on Genetic Knowledge Persistence Algorithm
《Asian Journal of Social Pharmacy》2025年第1期68-79,共12页Li Qian Zhang Wenfeng Yuan Hongmei 
Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algo...
关键词：ginsenoside genetic knowledge persistence algorithm(GKPA) high knowledge persistence patent(HKPP) genetic forward and backward path(GFBP) main path analysis 
Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis
《Chinese Herbal Medicines》2024年第4期548-557,共10页Yue Zhou Zi Wang Shen Ren Wei Li 
supported by the grants of National Natural Science Foundation of China (No. 82104465);Changchun Science & Technology Development Plan (No. 21ZGY11);the Scientific Research Planning Project of Jilin Provincial Department of Education (No. JJKH20220371KJ)。
Hepatocellular carcinoma(HCC) is one of the most prevalent malignancies globally, posing a major challenge to global health care. Protopanaxadiol ginsenosides(PDs) have been believed to significantly improve liver dis...
关键词：anti-hepatocellular carcinoma ginsenoside Rb_(1) ginsenoside Rd ginsenoside Rg_(3) ginsenoside Rg_5 ginsenoside Rh_(2) ginsenoside Rk_(1) network pharmacology protopanaxadiol ginsenosides 
Response of the Ginseng C_(2)H_(2)-Type Zinc Finger Protein Family PgZFPs Gene to Methyl Jasmonate Regulation
《Phyton-International Journal of Experimental Botany》2024年第11期3055-3071,共17页Yue Jiang Lingyu Liu Kangyu Wang Mingzhu Zhao Ping Chen Jun Lei Yanfang Wang Meiping Zhang Yi Wang Guang Chen 
This work was supported by the Department of Science and Technology of Jilin Province(20240101227JC,20210402043GH,20200801063GH,20190201264JC,20190103104JH,20180414077GH,and 20180101027JC);the Development and Reform Commission of Jilin Province(2016C064 and 2018C047-3).
The main active components of ginseng are ginsenosides,which play significant roles in treating cardiovascular diseases,cancer,and providing antioxidant effects.Ginsenosides are primarily synthesized through the mevalo...
关键词：GINSENOSIDES C_(2)H_(2)-type zincfinger protein family MeJA induction functional study SIT SITIENS FLC FLACCA MVA Mevalonate MEP 2-C-methyl-D-erythritol 4-phosphate GWAS Genome-wide association studies HPLC High-performance liquid chromatography 
Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng
《Acta Pharmaceutica Sinica B》2024年第9期4045-4058,共14页Ke Zhang Jinru Jia Ting Li Wenjing Liu Pengfei Tu Jian-Bo Wan Jun Li Yuelin Song 
the National Natural Science Foundation of China(No.81973444);National Administration of Traditional Chinese Medicine High level Key Discipline Construction Project of Traditional Chinese MedicinedChemistry of Chinese Materia Medica.
Although serving as the workhorse,MS/MS cannot fully satisfy the analytical requirements of quantitative sub-metabolome characterization.Because more information intrinsically correlates to more structural and concent...
关键词：Quantitative submetabolome characterization GINSENOSIDES Structural identification Notoginseng Full exciting energy ramp-MS3 spectrum 
Production of rare ginsenosides by biotransformation of Panax notoginseng saponins using Aspergillus fumigatus
《Bioresources and Bioprocessing》2024年第1期1076-1083,共8页Lian Yang Dongmei Lin Feixing Li Xiuming Cui Dengji Lou Xiaoyan Yang 
supported by the National Natural Science Foundation of China(Grant number:32060104).
Panax notoginseng saponins(PNS)are the main active components of Panax notoginseng.But after oral administration,they need to be converted into rare ginsenosides by human gut microbiota and gastric juice before they c...
关键词：Panax notoginseng saponins BIOTRANSFORMATION Rare ginsenosides Aspergillus fumigatus Antimicrobial activity 
Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway被引量：1
《Journal of Traditional Chinese Medicine》2023年第5期906-914,共9页LIU Bingbing LI Jieru SI Jianchao CHEN Qi YANG Shengchang JI Ensheng 
Natural Science Foundation of Hebei Province:the Central Regulatory Mechanism of Tanshinone IIA on AngiotensinⅡInduced Sympathetic Excitation in Intermittent Hypoxia(No.H2019423136);Fundamental Research Funds for the Provisional Universities of Hebei University of Chinese Medicine:a Study on the Protective Mechanism of Hydrogen on Chronic Intermittent Hypoxiainduced Microglia Inflammatory Response(No.YTZ2019001);a Study on the Molecular Mechanism of Improving Effect Danggui Buxue Decoction on Vascular Endothelial Cell Senescence in Chronic Intermittent Hypoxia through Nrf2/HO-1 Signaling Pathway(No.YXTD2021005);Graduate Innovation Fund of Hebei University of Chinese Medicine:the Effect of Jinlida Granules on the Myocardial Improvement of Chronic Intermittent Hypoxia Aggravated Diabetic Cardiomyopathy in db/db Mice(No.XCXZZBS2022013)。
OBJECTIVE:To examine the protective effect of ginsenoside Rb1(Rb1),the main component of Renshen(Radix Ginseng),on cardiomyopathy in db/db mice exposed to chronic intermittent hypoxia(CIH)and explore the potential und...
关键词：GINSENOSIDES diabetic cardiomyopathies oxidative stress AMP-activated protein kinases heme oxygenase-1 signal transduction chronic intermittent hypoxia 
Functional annotation map of natural compounds in traditional Chinese medicines library: TCMs with myocardial protection as a case被引量：1
《Acta Pharmaceutica Sinica B》2023年第9期3802-3816,共15页Xudong Xing Mengru Sun Zifan Guo Yongjuan Zhao Yuru Cai Ping Zhou Huiying Wang Wen Gao Ping Li Hua Yang 
supported by National Key R&D Program of China (2022YFC3500302);National Natural Science Foundation of China (No. 82173963);Key R&D Project of Shandong Province (No. 2021CXGC010507, China);Open Research Fund of Chengdu University of Traditional Chinese Medicine State Key Laboratory Southwestern Chinese Medicine Resources (No. 2022ZYXK2011015, China)。
The chemical complexity of traditional Chinese medicines(TCMs) makes the active and functional annotation of natural compounds challenging. Herein, we developed the TCMs-Compounds Functional Annotation platform(TCMs-C...
关键词：Knowledge discovery Metabolomics High content screening Cell phenotype GINSENG GINSENOSIDES 
Effect of WPI/Tween 80 mixed emulsifiers on physicochemical stability of ginsenosides nanoemulsions
《Food Bioscience》2023年第3期503-514,共12页Tao Yang Chang Liu Yan Zheng Tristan C.Liu Kexin Li Jianguo Liu Yaowei Liu Peng Zhou 
supported by the National Natural Science Foundation of China(No.32101864);the Natural Science Foundation of Jiangsu Province(BK20210457);Standard Foods(China)Co.,Ltd.
Conversion of major ginsenosides into minor ginsenosides improves its pharmacological effects.This study managed to convert major ginsenosides into minor ginsenoside Rg3 and compound K(CK)by optimizing acidolysis cond...
关键词：GINSENOSIDES Whey protein isolate Tween 80 NANOEMULSION Stability 
Biotransformation of ginsenosides from Korean wild-simulated ginseng(Panax ginseng C.A.Mey.)using the combination of high hydrostatic pressure,enzymatic hydrolysis,and sonication被引量：2
《Food Bioscience》2023年第3期1931-1939,共9页Il-Kyoon Mok Ho-yong Jung Hayeong Kim Doman Kim 
supported by the National Research Foundation of Korea,Republic of Korea(grant number 2022R1I1A1A01069773,2022R1F1A1063434,and 2022R1I1A1A01055913);the Technology Innovation Program,the Ministry of Trade,Industry&Energy,Republic of Korea(grant number 20009663);the OTTOGI Corporation,Republic of Korea,through the Research and Publication Project.
High hydrostatic pressure is a non-thermal processing technique for extracting functional compounds from herbal plants.This study aims to investigate the effectiveness of the combination of high hydrostatic pressure(H...
关键词：BIOTRANSFORMATION GINSENOSIDE High hydrostatic pressure Pectinex Sonication 
Effects of solid-state fermentation using R. oligosporus on the phytochemical composition of wild-simulated ginseng leaf and its biological properties
《Food Bioscience》2023年第2期532-540,共9页Juho Lim Hayeong Kim Sung Bae Park Kunal Pal Seung Wook Kim Doman Kim 
This work was supported by the National Research Foundation of Korea,Republic of Korea(grant number 2022R1I1A1A01069773,2022R1F1A1063434,and 2022R1A6A3A13064354);the Technology Innovation Program(grant number 20009663);the Ministry of Trade,Industry&Energy(MOTIE,Republic of Korea);the OTTOGI Corporation,Republic of Korea,through the Research and Publication Project.
Wild-simulated ginseng(WSG)grown in the mountains without specific facilities is widely used as functional foods in Asian countries due to its bioactive compounds,such as ginsenosides.However,long-time cultivation,low...
关键词：Wild-simulated ginseng leaf L-CARNITINE Solid-state fermentation R.oligosporus GINSENOSIDES Anti-inflammation Anti-lipid accumulation 
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