GINSENOSIDE

作品数:201被引量:1208H指数:19
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相关领域:医药卫生更多>>
相关作者:张均田池岛乔费晓方田代真一陈英杰更多>>
相关机构:沈阳药科大学吉林大学中国医学科学院中国协和医科大学长春中医学院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Ginsenoside Rh1 regulates the immune microenvironment of hepatocellular carcinoma via the glucocorticoid receptor
《Journal of Integrative Medicine》2024年第6期709-718,共10页Xiong-hui Wang Ya-lan Fu Yan-nan Xu Peng-cheng Zhang Tian-xiao Zheng Chang-quan Ling Ying-lu Feng 
supported by the Natural Science Foundation of Shandong Province(No.ZR2020MH39)。
Objective:Ginsenoside Rh1(G-Rh1)has been confirmed to inhibit the growth of breast cancer and colon cancer,but its therapeutic effect on hepatocellular carcinoma(HCC)is unclear.This study investigates the therapeutic ...
关键词:Ginsenoside Rh1 Glucocorticoid receptor MHC-I Immune microenvironment Hepatocellular carcinoma 
Ginsenoside Rb_(1) in cardiovascular and cerebrovascular diseases:A review of therapeutic potentials and molecular mechanisms
《Chinese Herbal Medicines》2024年第4期489-504,共16页Yueqin Song Chen Chen Wei Li 
supported by the grants of National Natural Science Foundation of China (No. 82104465)。
Cardiovascular and cerebrovascular diseases(CCVDs), which are circulatory system diseases caused by heart defects and vascular diseases, are the major noncommunicable diseases affecting global public health. With the ...
关键词:atherosclerosis cardiovascular and cerebrovascular diseases coronary heart disease ginsenoside Rb_(1) hypertension ischemic stroke periocular microvascular retinopathy 
Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis
《Chinese Herbal Medicines》2024年第4期548-557,共10页Yue Zhou Zi Wang Shen Ren Wei Li 
supported by the grants of National Natural Science Foundation of China (No. 82104465);Changchun Science & Technology Development Plan (No. 21ZGY11);the Scientific Research Planning Project of Jilin Provincial Department of Education (No. JJKH20220371KJ)。
Hepatocellular carcinoma(HCC) is one of the most prevalent malignancies globally, posing a major challenge to global health care. Protopanaxadiol ginsenosides(PDs) have been believed to significantly improve liver dis...
关键词:anti-hepatocellular carcinoma ginsenoside Rb_(1) ginsenoside Rd ginsenoside Rg_(3) ginsenoside Rg_5 ginsenoside Rh_(2) ginsenoside Rk_(1) network pharmacology protopanaxadiol ginsenosides 
Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng
《Acta Pharmaceutica Sinica B》2024年第9期4045-4058,共14页Ke Zhang Jinru Jia Ting Li Wenjing Liu Pengfei Tu Jian-Bo Wan Jun Li Yuelin Song 
the National Natural Science Foundation of China(No.81973444);National Administration of Traditional Chinese Medicine High level Key Discipline Construction Project of Traditional Chinese MedicinedChemistry of Chinese Materia Medica.
Although serving as the workhorse,MS/MS cannot fully satisfy the analytical requirements of quantitative sub-metabolome characterization.Because more information intrinsically correlates to more structural and concent...
关键词:Quantitative submetabolome characterization GINSENOSIDES Structural identification Notoginseng Full exciting energy ramp-MS3 spectrum 
Ginsenoside Rb_(1) improves human nonalcoholic fatty liver disease with liver organoids-on-a-chip
《Engineered Regeneration》2024年第3期283-294,共12页Hui Wang Yue Zhu Pengcheng Shi Xiangyang Li Qingyun Bu Yachun Li Xiaoyan You Guoping Zhao 
supported by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIP-CXRC-008);Major Project of Haihe Laboratory of Synthetic Biology(E2M9560201);National Natural Science Foundation of China(32301210&31200035);the China Postdoctoral Science Foundation(No.2022M713330).
Non-alcoholic fatty liver disease(NAFLD),a type of liver disease for which no treatment is currently approved,remains a major concern worldwide.It is manifested as simple hepatocyte steatosis and can develop into infl...
关键词:Nonalcoholic fatty liver Organoid Microfluidic platform Ginsenoside Rb_(1) Biological activity evaluation 
20(S)-Ginsenoside Rh2 inhibits hepatocellular carcinoma by suppressing angiogenesis and the GPC3‐mediated Wnt/β‑catenin signaling pathway被引量:1
《Acta Biochimica et Biophysica Sinica》2024年第5期688-696,共9页Linfei Xu Jing Li Ningning Hou Fang Han Xiaodong Sun Qinying Li 
supported by the grants from the National Natural Science Foundation of China(No.32101029);the Natural Science Foundation of Shandong Province(No.ZR2020QB164);the PhD Scientific Research Foundation(No.2021BKQ09);the Clinical Medical Research Foundation(No.2021wyfylcyj04);the Special Funds for Yuandu Scholars.
20(S)-Ginsenoside Rh2 has significant anti-tumor effects in various types of cancers,including human hepatocellular carcinoma(HCC).However,its molecular targets and mechanisms of action remain largely unknown.Here,we ...
关键词:20(S)-Rh2 ANGIOGENESIS hepatocellular carcinoma GPC3/Wnt/β-catenin 
A novel cabazitaxel liposomes modified with ginsenoside Rk1 for cancer targeted therapy被引量:1
《Acupuncture and Herbal Medicine》2024年第1期113-121,共9页Dandan Huang Zhongjie Tang Xiao Pu Tianqi Wang Feiyan Gao Chong Li 
supported by the National Natural Science Foundation of China(82373808);Chongqing Natural Science Foundation(cstc2021jcyj-bshX0125);Fundamental Research Funds for the Central Universities(SWURC2020001);the project for Chongqing University Innovation Research Group,Chongqing Education Committee(CXQT20006).
Objective:In this study,we aim to enhance the anti-prostate cancer efficacy of cabazitaxel(CTX)and reduce its immunosuppression and systemic toxicity by developing CTX-loaded liposomes modified with ginsenoside Rk1(Rk...
关键词:CABAZITAXEL Fungal infection Ginsenoside Rk1 Liposome-drug delivery system Prostate cancer 
Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis被引量:2
《Journal of Pharmaceutical Analysis》2024年第2期259-275,共17页Xue Bai Rongzhan Fu Yannan Liu Jianjun Deng Qiang Fei Zhiguang Duan Chenhui Zhu Daidi Fan 
supported by the National Key Research and Development Program,China(Grant Nos.:2021YFC2101500 and 2021YFC2103900);the National Natural Science Foundation of China(Grant Nos.:22278335 and 21978236);the Natural Science Basic Research Program of Shaanxi,China(Grant No.:2023-JC-JQ-17).
The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains unclear.Therefo...
关键词:Colorectal cancer GINSENOSIDE Immune cells Gut microbiota 
Transcriptome-Wide Identification and Functional Analysis of PgSQE08-01 Gene in Ginsenoside Biosynthesis in Panax ginseng C.A.Mey.
《Phyton-International Journal of Experimental Botany》2024年第2期313-327,共15页Lei Zhu Lihe Hou Yu Zhang Yang Jiang Yi Wang Meiping Zhang Mingzhu Zhao Kangyu Wang 
This work was supported by an award from the Department of Science and Technology of Jilin Province(20210402043GH and 20210204063YY).
Panax ginseng C.A.Mey.is an important plant species used in traditional Chinese medicine,whose primary active ingredient is a ginsenoside.Ginsenoside biosynthesis is not only regulated by transcription factors but als...
关键词:Panax ginseng pgSQE08-01 gene squalene epoxidase GINSENOSIDE ginseng hairy roots 
Ginsenoside F1 administration promotes UCP1-dependent fat browning and ameliorates obesity-associated insulin resistance
《Food Science and Human Wellness》2023年第6期2061-2072,共12页Yuhan Meng Weili Li Chenxing Hu Si Chen Haiyang Li Feifei Bai Lujuan Zheng Ye Yuan Yuying Fan Yifa Zhou 
supported by the National Natural Science Foundation of China[31872674];the Jilin Talent Development Foundation Grant[20200301018RQ];the Fundamental Research Funds for the Central Universities[CGZH202206].
Obesity-induced type 2 diabetes is mainly due to excessive free fatty acids leading to insulin resistance.Increasing thermogenesis is regarded as an effective strategy for hypolipidemia and hypoglycemia.Ginsenoside is...
关键词:Ginsenoside F1 Uncoupling protein 1 β3-Adrenergic receptor White adipose tissue browning Insulin resistance 
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