云南高校图书馆联盟文献共享服务平台- MHC-I

MHC-I: 作品数：45被引量：66H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：陈誉华张志勉韩顺昌郭振红杨一鸣更多>>; 相关机构：山东大学华南理工大学华中科技大学中国医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金江苏省自然科学基金国家重点基础研究发展计划山西省科技基础条件平台建设计划项目更多>>

In situ tumor cell engineering reverses immune escape to enhance immunotherapy effect: 《Acta Pharmaceutica Sinica B》2025年第1期627-641,共15页Shujun Liu Shijun Yuan Meichen Liu Jinhu Liu Shunli Fu Tong Gao Shuang Liang Xinyan Huang Xinke Zhang Yongjun Liu Zipeng Zhang Na Zhang; supported by the National Natural Science Foundation of China(82173757,81974498,82173756);the Natural Science Foundation of Shandong Province(ZR2023QH_(2)85,China);the Innovation Team of Shandong Higher School Youth Innovation Technology Program(2022KJ197,China);Talent Introduction(Promotion)Program of Shandong First Medical University&Shandong Academy of Medical Sciences.; The underlying cause of low response rates to existing immunotherapies is that tumor cells dominate tumor immune escape through surface antigen deficiency and inducing tumor immunosuppressive microenvironment(TIME).He...; 关键词：Tumor engineering MHC-I T cell recognition CD55 ICOSL^(+)B cell IMMUNOTHERAPY Immunogenic cell death CAR-T therapy

Ginsenoside Rh1 regulates the immune microenvironment of hepatocellular carcinoma via the glucocorticoid receptor: 《Journal of Integrative Medicine》2024年第6期709-718,共10页Xiong-hui Wang Ya-lan Fu Yan-nan Xu Peng-cheng Zhang Tian-xiao Zheng Chang-quan Ling Ying-lu Feng; supported by the Natural Science Foundation of Shandong Province(No.ZR2020MH39)。; Objective:Ginsenoside Rh1(G-Rh1)has been confirmed to inhibit the growth of breast cancer and colon cancer,but its therapeutic effect on hepatocellular carcinoma(HCC)is unclear.This study investigates the therapeutic ...; 关键词：Ginsenoside Rh1 Glucocorticoid receptor MHC-I Immune microenvironment Hepatocellular carcinoma

PACSIN1 promotes immunosuppression in gastric cancer by degrading MHC-I: 《Acta Biochimica et Biophysica Sinica》2024年第10期1473-1482,共10页Zhu Liu Xin Li Ali Muhammad Qiannan Sun Qi Zhang Yang Wang Yong Wang Jun Ren Daorong Wang; supported by the grant from the Yangzhou Key Laboratory of Basic and Clinical Transformation of Digestive and Metabolic Diseases(No.YZ2020159).; Gastric cancer(GC)is a common gastrointestinal system malignancy.PACSIN1 functions as an oncogene in various cancers.This study aims to investigate the potential of PACSIN1 as a target in GC treatment.Gene expression ...; 关键词：gastric cancer PACSIN1 AUTOPHAGY MHC-I CD8^(+)T cell

Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles被引量：1: 《Acta Pharmaceutica Sinica B》2024年第7期3218-3231,共14页Wen Zhang Yihui Zhai Ying Cai Xiang Gong Yunxuan Jiang Rong Rong Chao Zheng Binyu Zhu Helen He Zhu Hao Wang Yaping Li Pengcheng Zhang; financially supported by the National Natural Science Foundation of China(32371457,32171374 and 32130058);Shandong Laboratory Program(SYS202205,China).; Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with tr...; 关键词：MHC-I deficiency MACROPHAGE CD47 IMMUNOTHERAPY Triple-negative breast cancer PHAGOCYTOSIS Immune checkpoint Innate immunity

α5-nAChR与MHC-I在肺腺癌中的表达及相关性被引量：1: 《山东大学学报（医学版）》2024年第5期72-78,共7页王靖婷王璟鲁艺李静坦李强郏雁飞马晓丽; 山东省自然科学基金面上项目(ZR2021MH322)。; 目的探讨α5-烟碱型乙酰胆碱受体(alpha5-nicotinic acetylcholine receptor, α5-nAChR)与主要组织相容性复合体Ⅰ类分子(major histocompatibility complex class I molecule, MHC-I)在肺腺癌中的表达及相关性。方法 TCGA数据库分析C...; 关键词：α5-烟碱型乙酰胆碱受体脆性组氨酸三联体主要组织相容性复合体I类分子肺腺癌相关性

牙龈卟啉单胞菌FimA促进ESCC细胞MHC-I的降解与免疫抑制: 《食管疾病》2024年第1期1-7,共7页张旭东张秀森杨泽陈乐乐丁剑兰原翔; 河南省优秀青年科学基金项目(222300420041);河南省中青年卫生健康科技创新人才培养项目(YYKC2020040);河南省中原英才计划(育才系列)。; 目的探讨牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)感染食管鳞状细胞癌细胞后对主要组织相容性一类分子(MHC-I)的影响及其免疫调控机制。方法Western blot检测Pg感染KYSE-150细胞后主要毒力因子鞭毛蛋白(fimbriae,FimA)及MHC-I的表...; 关键词：食管鳞状细胞癌牙龈卟啉单胞菌自噬毒力因子肿瘤免疫微环境

猪德尔塔冠状病毒感染调控胞内关键抗原递呈分子MHC-I的表达: 《中国预防兽医学报》2022年第5期573-573,共1页LIU XIANG YIN LING-DAN XUE MEI; 猪德尔塔冠状病毒(PDCoV)是一种有囊膜的单股正义RNA病毒,全长约25.4 kb,是引起仔猪病毒性腹泻的主要病原之一。PDCoV能够引起猪的呕吐、腹泻、脱水、甚至死亡,其可感染不同日龄的猪,主要对仔猪危害较大,病死率在40%~80%。并且猪场存在...; 关键词：病毒混合感染人兽共患疾病养猪业跨种传播 RNA病毒主要病原冠状病毒流行病

Antigenic Peptide Loading into Major Histocompatibility Complex Class I Is Driven by the Substrate N-Terminus: 《CCS Chemistry》2022年第3期910-925,共16页Mengna Lin Honglin Xu Yi Shi Lin-Tai Da; The authors acknowledge the Natural Science Foundation of Shanghai(nos.20511101900,20ZR1427200,and 20ZR1425400).; Major histocompatibility complex class I(MHC-I),a key element of the acquired immune system,plays essential roles in activating CD8^(+)T cells by recognizing intracellular antigens derived from pathogens and cancer.As...; 关键词：antigenic peptide MHC-I molecule LOADING molecular dynamics simulations Markov state model

马MHC-I-B_(2)蛋白对马疱疹病毒1型胞内复制影响的研究: 《中国预防兽医学报》2021年第12期1263-1268,共6页郑学功刘建华孙佳琪车传忠祖力亚江·阿不都热合曼冉多良; 基于EHV-1新疆株马传染性鼻肺炎灭活疫苗研发(2017A01002-2-4)。; 为探明马MHC-I-B_(2)蛋白对马疱疹病毒1型(EHV-1)胞内复制的影响,本研究合成马MHC-I-B_(2)基因,并将其克隆至慢病毒表达载体,构建重组质粒pLVML-HA-MHC-IRES-Puro。利用慢病毒载体系统将pSPAX2、pMAD.2G、pLVML-HA-MHC-IRES-Puro共转染H...; 关键词：马疱疹病毒1型马MHCⅠ类分子细胞

Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson’s disease被引量：4: 《Neural Regeneration Research》2021年第12期2521-2527,共7页Bao-Yan Wang Yong-Yi Ye Chen Qian Hong-Bo Zhang Heng-Xu Mao Long-Ping Yao Xiang Sun Guo-Hui Lu Shi-Zhong Zhang; This work was supported by the National Natural Science Foundation of China,Nos.81671240(to SZZ),81560220(to GHL);the Youth Science Foundation of Jiangxi Province of China,No.20151BAB215014(to GHL);Health and Family Planning Commission of Jiangxi Province of China,No.20195109(to GHL)。; The expression of major histocompatibility complex class I(MHC-I),a key antigen-presenting protein,can be induced in dopaminergic neurons in the substantia nigra,thus indicating its possible involvement in the occurre...; 关键词：antigen presentation AUTOIMMUNE CD8+T cell dopaminergic neuron major histocompatibility complex class I mitochondria NEUROINFLAMMATION oxidative stress Parkinson’s disease PINK1

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