p-mTOR在Ⅰ～Ⅲ期非小细胞肺癌组织中的表达及其与预后的关系  

The expression of p-mammalian target of rapamycin in non-small cell lung cancer and its prognostic significance

作　　者：刘红兵[1] 宋勇[1] 吴颖[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院呼吸科,江苏南京210002

出　　处：《中国呼吸与危重监护杂志》2008年第5期354-357,I0001,I0002,共6页Chinese Journal of Respiratory and Critical Care Medicine

基　　金：江苏省六大人才高峰基金课题(编号:2005A3)

摘　　要：目的探讨磷酸化的哺乳动物雷帕霉素靶蛋白(p-mTOR)在非小细胞肺癌(NSCLC)中的表达及其对预后的预测价值。方法运用免疫组织化学EnVision法检测59例NSCLC肺癌组织和10例非肺癌组织(3例肺结核和7例炎性假瘤)中p-mTOR蛋白的表达。结果p-mTOR在肺良性疾病组均为阴性,在NSCLC组织中表达的阳性率为40.7%,显著高于肺良性疾病组(2=6.237,P=0.013);p-mTOR在NSCLC组织中的表达与性别、年龄和pTNM分期有关,而与其他临床病理参数(肿瘤大小、病理类型和淋巴结转移情况)无明显相关性。Kaplan-Meire生存分析显示,p-mTOR与生存期无明显相关(Log rank检验P=0.055)。结论检测p-mTOR有助于肺部良恶性疾病的鉴别,单独p-mTOR不能作为判断NSCLC预后的参考指标。Objective To study the p-mammalian target of rapamycin （p-roTOR） expression and its prognostic significance in non-small cell lung cancer （NSCLC）. Methods Immunohistochemical staining of EnVision was applied to investigate the expression of p-mTOR in lung specimens from 59 cases with NSCLC and 10 cases with benign pulmonary diseases（ 3 pulmonary tuberculosises and 7 inflammatory pseudotumors）. Results The positive rate of p-mTOR was 40. 7% in NSCLC which was significantly higher than that in the benign pulmonary diseases （ X^2 = 6. 237, P = 0. 013 ）. The expression of p-mTOR was closely correlated with age, sex and pTNM stage. Kaplan-Meire survival analysis revealed that the expression of p-mTOR was not correlated significantly with survival days （ Log rank test P = 0. 055 ）. Conclusion P-roTOR might be a biomark for differential diagnosis of malignant lung disease, but has poor prognostic value.

关 键 词：磷酸化的哺乳动物雷帕霉素靶蛋白 非小细胞肺癌 预后 

分 类 号：R734.2[医药卫生—肿瘤] R446[医药卫生—临床医学]