盐酸川芎嗪经皮给药系统的制备及体外释放和透皮研究  

Preparation,in vitro Release and Percutaneous Penetration of Ligustrazine Hydrochloride Transdermal Delivery System

作　　者：窦义之[1] 滕虎[1] 汪晴[1] 孙玉明[1] 马诗琳[1] 

机构地区：[1]大连理工大学精细化工国家重点实验室制药工程,辽宁大连116012

出　　处：《中国医药工业杂志》2008年第10期745-749,共5页Chinese Journal of Pharmaceuticals

基　　金：国家科技支撑计划项目(2006BAI09B08)

摘　　要：用盐酸川芎嗪作为模型药物,将阿拉伯胶与聚丙烯酸酯压敏胶共混,制备了一种微观非均相、宏观均相的经皮给药系统,并考察了非均相结构对药物体外释放及透皮速率的影响。结果表明,阿拉伯胶含量为15%时可抑制载药量为5%的贴片中药物析晶,同时增加盐酸川芎嗪的体外释放与裸鼠皮肤的透过量,且阿拉伯胶的加入量对于贴片的黏附性无明显影响。A novel microheterogeneous and macrohomogeneous transdermal delivery system loaded with ligustrazine hydrochloride was prepared by blending acrylic pressure-sensitive adhesive （PSA） with gum arabic （GA）. The effect of the structure of microheterogeneous matrix on the in vitro release and permeation profiles of the drug through the hairless mice skin were investigated. The results showed that 15 % GA could inhibit the drug to crystallize out in the patches containing 5 % ligustrazine hydrochloride, and increase the in vitro release and permeation amount. There was no significant effect of amount of GA on adhesive property of the patches.

关 键 词：经皮给药系统 微观非均相结构 盐酸川芎嗪 聚丙烯酸酯压敏胶 阿拉伯胶 

分 类 号：R944.9[医药卫生—药剂学]