合成6-氟-2-甲基茚酮的新方法  

A New Synthesis Method of 6-Fluoro-2-methylindanone

作　　者：戴立言[1] 贺电[1] 王晓钟[1] 陈英奇[1] 

机构地区：[1]浙江大学材料与化工学院制药工程研究所,浙江杭州310027

出　　处：《合成化学》2008年第5期614-616,共3页Chinese Journal of Synthetic Chemistry

摘　　要：对氟氯苄与甲基丙二酸二乙酯经缩合、碱性水解、脱羧、SOCl2酰氯化、分子内Friedel-Crafts酰基化等反应合成非甾体抗炎药舒林酸的中间体——6-氟-2-甲基茚酮,总收率57.0%,其结构经1H NMR,GC-MS和元素分析表征。An intermediate of Sulindae, 6-fluoro-2-methylindanone, was synthesized from 4-fluorobenzyl chloride via condensation with diethyl methyl malonate, hydrolysis in the presence of KOH, decarboxylation, aeyl chlorination with SOC12, and intermolecular Friedel - Crafts reaction. The overall yield was up to 57.0%. The structure was characterized by ^1H NMR, GC-MS and elemental analysis.

关 键 词：茚酮 Friedel—Crafts反应 缩合 合成 

分 类 号：TQ242.2[化学工程—有机化工] TB333[一般工业技术—材料科学与工程]